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ECHISTATIN

Product Name
ECHISTATIN
CAS No.
154303-05-6
Chemical Name
ECHISTATIN
Synonyms
Cys8-Cys37;Cys7-Cys32;Cys20-Cys39);Echistatin α1;ECHISTATIN,A1 ISOFORM;Echistatin, α1 isoform;Echistatin,α1 isoform，TFA salt;M.W. 5417.05 C217H341N71O74S9 (Disulfide bonds between Cys2 and Cys11/Cys7 and Cys32/ Cys8 and Cys37/Cys20 and Cys39);H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH;H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH(Disulfide bridge：Cys2-Cys11
CBNumber
CB4973021
Molecular Formula
C217H341N71O74S9
Formula Weight
5417.04574
MOL File
154303-05-6.mol
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ECHISTATIN Property

storage temp. 
-20°C
form 
Powder
biological source
Echis carinatus
Water Solubility 
Soluble to 1 mg/ml in water
Sequence
Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr (Disulfide bridge:Cys2-Cys11;Cys7-Cys32;Cys8-Cys37;Cys20-Cys39)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

ApexBio Technology
Product number
B5391
Product name
Echistatin,α1isoform
Packaging
100ug
Price
$528
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002517
Product name
ECHISTATIN
Purity
95.00%
Packaging
0.1MG
Price
$800.76
Updated
2021/12/16
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ECHISTATIN Chemical Properties,Usage,Production

Uses

Echistatin has been used:

  • as an inhibitor of integrin function to study the role of microfibril-associated glycoprotein-1 (Magp1) in the morphogenesis of vascular structures
  • for the preparation of microbubbles targeted to αvβ3 integrins in tumor angiogenesis imaging
  • as a conjugate to αvβ3 in flow cytometric binding studies

General Description

Echistatin is a single chain 49 amino acid residue protein, which prevents the aggregation of platelets. It has an isoelectric point (pI) of 8.3 and a molecular weight of 5400. This peptide is present in the venom of Echis carinatus, which is a saw-scaled viper. It contains the arginine-glycine-aspartic (RGD) acid sequence, which is present in proteins that bind to glycoprotein IIb/IIIa complex. It shares the proline-arginine-asparagine-proline sequence with the Aα chain of human fibrinogen. This protein is a member of disintegrin family, which prevents cell adhesion. With regards to molecular weight, echistatins are the smallest member of disintegrin family, and contains four isoforms called, α1, α2, β and γ.

Biochem/physiol Actions

Echistatin is a disintegrin, which prevents the aggregation of platelets. They interact with and prevent the binding of fibrinogen to their receptors on the membrane of platelets. It also inhibits platelet aggregation mediated by epinephrine, thrombin, collagen, or platelet-activating factor. Studies in isolated osteoclasts show that this peptide inhibits bone resorption by osteoclasts, most probably by damaging adhesion structures.

IC 50

αvβ3; α5β1; αIIbβ3

storage

Store at -20°C

ECHISTATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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154303-05-6, ECHISTATINRelated Search:

TCS 184 D-Trp(34) neuropeptide Y AC-LEU-ASP-GLN-TRP-PHE-GLY-NH2 PTH (1-84) (HUMAN) Compstatin control peptide GATX2 APETx2 ω-Agatoxin TK Cyclo[L-α-aspartyl-D-phenylalanyl-L-lysyl-N5-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-L-ornithylglycyl], 1,1-dimethylethyl ester MM 54 (Gly1,Ser3·22,Gln4·34,Thr6,Arg19,Tyr21,Ala23·31,Aib32)-Pancreatic Polypeptide (human) Vosoritide acetate PDZ1 DOMAIN INHIBITOR PEPTIDE

  • M.W. 5417.05 C217H341N71O74S9 (Disulfide bonds between Cys2 and Cys11/Cys7 and Cys32/ Cys8 and Cys37/Cys20 and Cys39)
  • Echistatin, α1 isoform
  • H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH
  • ECHISTATIN,A1 ISOFORM
  • Cys20-Cys39)
  • Cys7-Cys32
  • Cys8-Cys37
  • H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg-Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH(Disulfide bridge：Cys2-Cys11
  • Echistatin,α1 isoform，TFA salt
  • Echistatin α1
  • 154303-05-6
  • Fibrinogen/Thrombin