5-METHOXY -ISATOIC ANHYDRIDE
- Product Name
- 5-METHOXY -ISATOIC ANHYDRIDE
- CAS No.
- 37795-77-0
- Chemical Name
- 5-METHOXY -ISATOIC ANHYDRIDE
- Synonyms
- Nsc163035;6-methoxy-1H-3,1-benzoxazine-2,4-dione;6-Methoxy-4H-3,1-benzoxazine-2,4(1H)-dione;6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 6-methoxy-;6-methoxy-2H-benzo[d][1,3]oxazine-2,4(1H)-dione;6-methoxy-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione;6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione, 6-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione
- CBNumber
- CB51118947
- Molecular Formula
- C9H7NO4
- Formula Weight
- 193.16
- MOL File
- 37795-77-0.mol
5-METHOXY -ISATOIC ANHYDRIDE Property
- Melting point:
- 244-246℃ (decomposition)
- Density
- 1.376±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 10.45±0.20(Predicted)
- form
- crystalline powder
- color
- Chocolate brown
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- OR400011
- Product name
- 5-Methoxyisatoicanhydride
- Packaging
- 250mg
- Price
- $47
- Updated
- 2021/12/16
- Product number
- 4H26-1-06
- Product name
- 5-Methoxyisatoic anhydride
- Packaging
- 250mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- OR400011
- Product name
- 5-Methoxyisatoicanhydride
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- 4H26-1-06
- Product name
- 5-Methoxyisatoic anhydride
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- OR400011
- Product name
- 5-Methoxyisatoicanhydride
- Packaging
- 5g
- Price
- $254
- Updated
- 2021/12/16
5-METHOXY -ISATOIC ANHYDRIDE Chemical Properties,Usage,Production
Uses
5-Methoxyisatoic Anhydride is a reagent in the preparation of 18F-labeled radiotracers for GABAA receptor PET imaging.
Synthesis
6705-03-9
37795-77-0
General procedure for the synthesis of 6-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione from 2-amino-5-methoxybenzoic acid: 5-methoxy-o-toluic acid (30 g, 179 mmol) was dissolved in a mixture of water (1.2 L) and concentrated hydrochloric acid. Triphosgene (63.8 g, 215 mmol) was then added, followed by concentrated hydrochloric acid (15 mL). The reaction mixture was stirred at room temperature for 3-4 hours until the reaction was complete (monitored by thin layer chromatography on silica gel plates). Upon completion of the reaction, a white solid precipitated from the solution. The solid was collected by filtration and washed with a large amount of water (4 L). The resulting solid was dried under vacuum to afford anhydride (30.7 g) of 89% purity in the following yield: melting point 237-239 °C; 1H NMR (300 MHz, CDCl3) δ 3.65 (s, 3H), 7.11 (d, 1H, J=8.9 Hz), 7.35 (dd, 1H, J=8.9 Hz, 2.7 Hz), 7.19 (d, 1H J=2.7 Hz), 11.61 (bs, 1H). The spectral data were in agreement with the values reported in the literature [27]. The product can be used directly in the next step of the reaction without further purification. Note: Triphosgene is toxic and requires extra care when handling.
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 4, p. 1492 - 1500
[2] Organic Process Research and Development, 2013, vol. 17, # 8, p. 1042 - 1051
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 550 - 560
5-METHOXY -ISATOIC ANHYDRIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXY -ISATOIC ANHYDRIDE manufacturers
- Product
- 6-Methoxy-2H-3,1-benzoxazine-2,4(1H)-dione 37795-77-0
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-29
- Product
- 5-Methoxyisatoic anhydride 37795-77-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-20