4-P-AMINOPHENYL-1-BOC-PIPERIDINE

Product Name: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE
CAS No.: 170011-57-1
Chemical Name: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE
Synonyms: 4-(1-Boc-4-piperidyl)aniline;1-N-Boc-(4-aminophenyl)piperidine;4-P-AMINOPHENYL-1-BOC-PIPERIDINE;4-(1-Boc-piperidin-4-yl)-phenylami;4-(1-Boc-piperidin-4-yl)-phenylamine, 98%;1-(tert-Butoxycarbonyl)-4-(4-aminophenyl)piperidine;tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate;tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate;4-(4-Aminophenyl)piperidin-1-carboxylic acid tert-butyl ester;4-(4-Aminophenyl)piperidine-1-carboxylic acid tert-butyl ester
CBNumber: CB51119429
Molecular Formula: C16H24N2O2
Formula Weight: 276.37
MOL File: 170011-57-1.mol

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4-P-AMINOPHENYL-1-BOC-PIPERIDINE Property

Melting point:: 119 °C
Boiling point:: 412.7±45.0 °C(Predicted)
Density: 1.100±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.97±0.10(Predicted)
color: White to Yellow to Green
InChI: InChI=1S/C16H24N2O2/c1-16(2,3)20-15(19)18-10-8-13(9-11-18)12-4-6-14(17)7-5-12/h4-7,13H,8-11,17H2,1-3H3
InChIKey: YRLQFRXDWBFGMK-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C2=CC=C(N)C=C2)CC1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5832
Product name: tert-Butyl 4-(4-Aminophenyl)piperidine-1-carboxylate
Purity: >97.0%(HPLC)
Packaging: 200mg
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: B5832
Product name: tert-Butyl 4-(4-Aminophenyl)piperidine-1-carboxylate
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $65
Updated: 2025/07/31

TRC

Product number: B621100
Product name: 1-Boc-4-(4-aminophenyl)piperidine
Packaging: 1g
Price: $195
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-EK
Product name: tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51224
Product name: 1-Boc-4-(4-aminophenyl)piperidine
Packaging: 1g
Price: $90
Updated: 2021/12/16

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4-P-AMINOPHENYL-1-BOC-PIPERIDINE Chemical Properties,Usage,Production

Uses

1-Boc-4-(4-aminophenyl)piperidine is a useful synthetic intermediate used in the synthesis of FMS inhibitors that may be useful in treating rheumatoid arthritis and other chronic inflammatory diseases.

Synthesis

873454-43-4

170011-57-1

General procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate from tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate: 4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.35 g, 1.2 mmol) (prepared in previous step) was dissolved in methanol and added to a 10% Pd/C catalyst and hydrogenated at 20 psi hydrogen pressure for 1 hour. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated to give 0.35 g (100% yield) of tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate as a yellow solid. Mass spectrum (ESI, m/z): the calculated value of [M+H]+ for C16H24N2O2 was 277.2 and the measured value was 277.1.

References

[1] Patent: WO2006/47277, 2006, A2. Location in patent: Page/Page column 58-59
[2] Patent: US2006/281788, 2006, A1. Location in patent: Page/Page column 55
[3] Patent: US2008/51402, 2008, A1. Location in patent: Page/Page column 41
[4] Patent: US2008/114007, 2008, A1. Location in patent: Page/Page column 90
[5] Patent: US2007/60577, 2007, A1. Location in patent: Page/Page column 53

4-P-AMINOPHENYL-1-BOC-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-P-AMINOPHENYL-1-BOC-PIPERIDINE Suppliers

Americas 1 China 123 Europe 1 Germany 1 India 3 Japan 1 United Kingdom 2 United States 14 Global 146

SanoChem (Chengdu) Tech. Co., Ltd.

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Pure Chemistry Scientific Inc.

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Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from 4-P-AMINOPHENYL-1-BOC-PIPERIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-BOC-4-(4-AMINOPHENYL)PIPERIDINE 170011-57-1
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE 170011-57-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-23

170011-57-1, 4-P-AMINOPHENYL-1-BOC-PIPERIDINE Related Search:

tert-butyl 4-(4-(2-aminoethyl)phenyl)piperidine-1-carboxylate tert-butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate hydrochloride TERT-BUTYL 4-(4-(AMINOMETHYL)PHENYL)PIPERIDINE-1-CARBOXYLATE tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate tert-butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 1-Boc-piperidine 1-Boc-3-(3-Aminophenyl)Piperidine 1-Boc-3-(4-Aminophenyl)Piperidine 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Boc-4-(3-Aminophenyl)Piperidine 1-Boc-3-(2-Aminophenyl)Piperidine 1-Boc-4-(2-Aminophenyl)Piperidine 4-(4-AMINOPHENYL)-PIPERIDINE 4-(1-METHYL-PIPERIDIN-4-YL)-ANILINE 4-P-AMINOPHENYL-1-BOC-PIPERIDINE

4-P-AMINOPHENYL-1-BOC-PIPERIDINE

1-N-Boc-(4-aminophenyl)piperidine

4-(4-Aminophenyl)piperidine-1-carboxylic acid tert-butyl ester

1-Piperidinecarboxylicacid,4-(4-aMinophenyl)-,1,1-diMethylethylester

4-(1-Boc-piperidin-4-yl)-phenylamine, 98%

tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate

4-(4-aminophenyl)-1-piperidinecarboxylic acid tert-butyl ester

1-(tert-Butoxycarbonyl)-4-(4-aminophenyl)piperidine

4-(1-Boc-piperidin-4-yl)-phenylami

4-(1-Boc-4-piperidyl)aniline

tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate

4-(4-Aminophenyl)piperidin-1-carboxylic acid tert-butyl ester

170011-57-1