4-Difluoromethoxyphenylboronic acid pinacol ester

Product Name: 4-Difluoromethoxyphenylboronic acid pinacol ester
CAS No.: 887757-48-4
Chemical Name: 4-Difluoromethoxyphenylboronic acid pinacol ester
Synonyms: 4-difluoromethoxyphenylboronic;4-Difluoromethoxyphenylboronic acid pinacol ester;2-[4-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-diox...;2-(4-(difluoromethoxy)phenyl)-4,4,5-trimethyl-1,3,2-dioxaborolane;2-(4-(DifluoroMethoxy)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-[4-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-
CBNumber: CB51177160
Molecular Formula: C13H17BF2O3
Formula Weight: 270.08
MOL File: 887757-48-4.mol

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4-Difluoromethoxyphenylboronic acid pinacol ester Property

Boiling point:: 319.3±37.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to light brown Solid
InChI: InChI=1S/C13H17BF2O3/c1-12(2)13(3,4)19-14(18-12)9-5-7-10(8-6-9)17-11(15)16/h5-8,11H,1-4H3
InChIKey: BPFSJXBWEVRJFH-UHFFFAOYSA-N
SMILES: O1C(C)(C)C(C)(C)OB1C1=CC=C(OC(F)F)C=C1

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D447558
Product name: 4-Difluoromethoxyphenylboronicacidpinacolester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D447558
Product name: 4-Difluoromethoxyphenylboronicacidpinacolester
Packaging: 250mg
Price: $95
Updated: 2021/12/16

TRC

Product number: D447558
Product name: 4-Difluoromethoxyphenylboronicacidpinacolester
Packaging: 1g
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 091787
Product name: 2-(4-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Purity: 95+%
Packaging: 1g
Price: $284
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0005778
Product name: 4-DIFLUOROMETHOXYPHENYLBORONIC ACID PINACOL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $498.12
Updated: 2021/12/16

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4-Difluoromethoxyphenylboronic acid pinacol ester Chemical Properties,Usage,Production

Synthesis

5905-69-1

73183-34-3

887757-48-4

A. General procedure for the synthesis of 2-(4-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane: Under nitrogen protection, 1-bromo-4-(difluoromethoxy)benzene (1 g, 4.48 mmol), pinacol ester of bis(boronic acid) (1.2 g, 4.71 mmol), potassium acetate (1.3 g, 13.4 mmol), and PdCl2(dppf)-CH2Cl2 adduct (0.18 g, 0.22 mmol) were dissolved in DMF (15 mL) at 90 °C for 1 h. The reaction was stirred. After completion of the reaction, the reaction mixture was diluted with dichloromethane, washed sequentially with water, saturated NaHCO3 solution and brine, and the organic phase was dried with anhydrous MgSO4 and concentrated. The crude product was purified by ISCO fast chromatography (silica gel column, eluent 100:0 to 50:50 hexane/ethyl acetate gradient) to afford the target product 2-(4-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.12 g, 3.32 mmol, yield 74.0%) as a brown oil.

References

[1] Organic Process Research and Development, 2018, vol. 22, # 4, p. 557 - 561
[2] Patent: WO2010/104830, 2010, A1. Location in patent: Page/Page column 98-99
[3] Patent: US2012/329802, 2012, A1. Location in patent: Page/Page column 33
[4] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 49
[5] Patent: WO2009/26276, 2009, A1. Location in patent: Page/Page column 49-50

4-Difluoromethoxyphenylboronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Difluoromethoxyphenylboronic acid pinacol ester Suppliers

China 68 India 1 United Kingdom 1 United States 7 Global 77

Suzhou Victorypharm Co.,Ltd.

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View Lastest Price from 4-Difluoromethoxyphenylboronic acid pinacol ester manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-(4-(DIFLUOROMETHOXY)PHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 887757-48-4
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-07-03

Career Henan Chemical Co

Product: 4-Difluoromethoxyphenylboronic acid pinacol ester 887757-48-4
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

887757-48-4, 4-Difluoromethoxyphenylboronic acid pinacol esterRelated Search:

Boronic acid, [4-(difluoromethoxy)phenyl]- (9CI) 4,4,5,5-TETRAMETHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-1,3,2-DIOXABOROLANE 2-(2-(Bromomethyl)-4-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4-Difluoromethoxyphenylboronic acid pinacol ester

4-Difluoromethoxyphenylboronic acid pinacol ester

2-(4-(difluoromethoxy)phenyl)-4,4,5-trimethyl-1,3,2-dioxaborolane

2-(4-(DifluoroMethoxy)phenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

4-difluoromethoxyphenylboronic

1,3,2-Dioxaborolane, 2-[4-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-

2-[4-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-diox...

887757-48-4

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