Robalzotan

Product Name: Robalzotan
CAS No.: 169758-66-1
Chemical Name: Robalzotan
Synonyms: NAD 299;AZD7371;AZD 7371;AZD-7371;Robalzotan;NAD299; NAD-299;Unii-I18m56ogme;Robalzotan [inn];NAD 299 hydrochlorid;NAD 299 hydrochloride
CBNumber: CB51179669
Molecular Formula: C18H23FN2O2
Formula Weight: 318.39
MOL File: 169758-66-1.mol

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Robalzotan Property

Boiling point:: 429.9±45.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
pka: 15.72±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 3282
Product name: NAD299hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $169
Updated: 2021/12/16

Tocris

Product number: 3282
Product name: NAD299hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $710
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009352
Product name: ROBALZOTAN
Purity: 95.00%
Packaging: 10MG
Price: $721.59
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009352
Product name: ROBALZOTAN
Purity: 95.00%
Packaging: 50MG
Price: $1327.97
Updated: 2021/12/16

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Robalzotan Chemical Properties,Usage,Production

Uses

NAD 299 Hydrochloride is a selective, high affinity 5-HT1A antagonist, used in psychotropic drug development.

Biological Activity

Selective, high affinity 5-HT 1A receptor antagonist (K i = 0.6 nM in vitro ).

in vivo

Robalzotan (1-100 μg/kg; i.v.) significantly increases the activity of such neurons at 5 μg/kg in rats, and reverses the acute inhibitory effect of citalopram (HY-121203) (300 μg/kg i.v.) or paroxetine (HY-122272) (100 μg/kg, i.v.) on the activity of 5-HT neurons in the dorsal raphe nucleus in rats^[1].
Robalzotan (5, 50 μg/kg; i.v.) increases the firing rate of the 5-HT cells^[1].
Robalzotan (2-100 μg/kg; i.v.) occupies 5-HT1A receptors in a dose-dependent in monkeys^[2].
Robalzotan (0.3; 1 and 3 μmol/kg s.c) causes a dose-dependent increase of extracellular ACh levels in the rat FC^[3].

IC 50

5-HT_1A Receptor

Robalzotan Preparation Products And Raw materials

Raw materials

Preparation Products

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Robalzotan Suppliers

China 18 United Kingdom 1 United States 4 Global 23

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Shanghai Tube Pharmaceutical Co., Ltd.

Tel: 021-54338626 18017892860
Fax: 021-54338626
Email: sales@tubepharm.com
Country: China
ProdList: 2572
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Foshan Heshuo Pharm technology Co., ltd

Tel: 15363639686
Email: heshuoyiyao@hotmail.com
Country: China
ProdList: 2376
Advantage: 58

169758-66-1, RobalzotanRelated Search:

(3R,6R)-2,7-DIMETHYL-3,6-OCTANEDIOL (3R,4R)-PYRROLIDINE-3,4-DIOL TRIISOPROPYL-AMINE [2-(2-METHOXYPHENYL)ETHYL](PROPAN-2-YL)AMINE Dimethylaminoethanol bitartrate Robalzotan CHEMBRDG-BB 9071484

Robalzotan

Robalzotan [inn]

Unii-I18m56ogme

(3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamidehydrochloride

NAD 299

(R)-3-(DicyclobutylaMino)-8-fluorochroMan-5-carboxaMide

NAD 299 hydrochloride (Robalzotan)

NAD 299 hydrochloride

(3R)-3-[di(cyclobutyl)amino]-8-fluoro-3,4-dihydro-2H-chromene-5-carboxamide

NAD299; NAD-299

2H-1-Benzopyran-5-carboxamide, 3-(dicyclobutylamino)-8-fluoro-3,4-dihydro-, (3R)-

NAD 299 hydrochlorid

AZD 7371

AZD7371

AZD-7371

169758-66-1

C18H23FN2O2HCl