CC-99282

Product Name: CC-99282
CAS No.: 2379572-34-4
Chemical Name: CC-99282
Synonyms: CC-99282;golcadomide;CC-99282 ，E1212;Golcadomide (CC-99282);Golcadomide (Synonyms: CC-99282);(S)-2-(2,6-Dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione;2-[(3S)-2,6-dioxo-3-piperidyl]-4-[[2-fluoro-4-[(3-morpholinoazetidin-1-yl)methyl]phenyl]methylamino]isoindoline-1,3-dione
CBNumber: CB511959499
Molecular Formula: C28H30FN5O5
Formula Weight: 535.58
MOL File: 2379572-34-4.mol

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CC-99282 Property

form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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CC-99282 Chemical Properties,Usage,Production

Uses

Golcadomide (CC-99282) is a potent and orally active CRBN E3 ligase modulator (CELMoD). Golcadomide interacts with the CRL4 CRBN E3 ubiquitin ligase substrate receptor CRBN, inducing the recruitment and ubiquitin-mediated proteasomal degradation of the transcription factors Ikaros and Aiolos. Golcadomide shows potential for research in cancer-related fields, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL)[1][2].

in vivo

Golcadomide (1 mg/kg) monotherapy results in modest tumor growth inhibition, whereas the combination of Golcadomide (1 mg/kg) and rituximab (10 mg/kg) results in tumor regression in 100% of animals in the WSU-DLCL2 model and the FL xenograft model.

IC 50

Cereblon

References

[1] J.-M. Michot, et al. A PHASE 1, MULTICENTER, OPEN-LABEL STUDY OF CC-99282 ALONE AND IN COMBINATION WITH RITUXIMAB IN PATIENTS WITH RELAPSED OR REFRACTORY NON-HODGKIN LYMPHOMAS. Hematological Oncology. Volume 39, Issue S2, Jun. 2021.
[2] Carrancio S, et al. CC-99282 is a novel cereblon (CRBN) E3 ligase modulator (CELMoD) agent with enhanced tumoricidal activity in preclinical models of lymphoma[J]. Blood, 2021, 138: 1200.

CC-99282 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-99282 Suppliers

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2379572-34-4, CC-99282Related Search:

CC-99282

golcadomide

Golcadomide (Synonyms: CC-99282)

2-[(3S)-2,6-dioxo-3-piperidyl]-4-[[2-fluoro-4-[(3-morpholinoazetidin-1-yl)methyl]phenyl]methylamino]isoindoline-1,3-dione

(S)-2-(2,6-Dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione

CC-99282 ，E1212

Golcadomide (CC-99282)

2379572-34-4