4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Product Name: 4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS No.: 2758432-00-5
Chemical Name: 4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms: Thalidomide-O-C3-azide;Thalidomide 4'-ether-alkylC3-azide;4-(3-azidoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CBNumber: CB511979228
Molecular Formula: C16H15N5O5
Formula Weight: 357.33
MOL File: 2758432-00-5.mol

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4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties,Usage,Production

Uses

Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs[1].

Biological Activity

Thalidomide 4'-ether-alkylC3-azide is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC3 linker with a terminal azide ready for conjugation to a target protein ligand.

storage

Store at -20°C

References

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. DOI:10.1038/nature13527

4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Preparation Products And Raw materials

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4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Suppliers

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2758432-00-5, 4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneRelated Search:

Thalidomide-NH-C4-NH-Boc 2-(2,6-DIOXOPIPERIDIN-3-YL)-5-FLUORO-6-(PIPERAZIN-1-YL)ISOINDOLINE-1,3-DIONE HCL 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione

4-(3-azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Thalidomide-O-C3-azide

Thalidomide 4'-ether-alkylC3-azide

4-(3-azidoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

2758432-00-5