(3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
- Product Name
- (3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
- CAS No.
- 70741-38-7
- Chemical Name
- (3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
- Synonyms
- 8DHC;Δ5,8 Sterol;Δ5,8-Cholest-dienol;8-Dehydrocholesterol;Cholesta-5,8-dien-3β-ol;8(9)-dehydrocholesterol;cholesta-5,8(9)-dien-3-ol;Cholesta-5,8(9)-dien-3b-ol;cholesta-5,8(9)-dien-3β-ol;cholesta-5,8-dien-3 beta-ol
- CBNumber
- CB51235653
- Molecular Formula
- C27H44O
- Formula Weight
- 384.64
- MOL File
- 70741-38-7.mol
(3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol Property
- Melting point:
- 147-148 °C(Solv: chloroform (67-66-3); acetone (67-64-1))
- Boiling point:
- 492.1±44.0 °C(Predicted)
- Density
- 1.00±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.00±0.70(Predicted)
- color
- White to Pale Yellow
N-Bromosuccinimide Price
- Product number
- 25970
- Product name
- 8-dehydro Cholesterol
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 25970
- Product name
- 8-dehydro Cholesterol
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 25970
- Product name
- 8-dehydro Cholesterol
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- D230295
- Product name
- 8-Dehydrocholesterol
- Packaging
- 100mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- CS-0059524
- Product name
- 8-Dehydrocholesterol
- Packaging
- 50mg
- Price
- $650
- Updated
- 2021/12/16
(3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol Chemical Properties,Usage,Production
Description
8-dehydro Cholesterol (8-DHC) is an isomer of the cholesterol precursor 7-DHC . It accumulates in tissues and plasma in patients with Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in DHCR7, the gene encoding 3β-hydroxysterol-Δ7-reductase, and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. 8-DHC levels are increased in serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 .
Uses
8-Dehydrocholesterol is an intermediate in the synthesis of Zymostenol, which is the derivative of Zymosterol (Z701520), an sterol intermediate in the biosynthesis of cholesterol (C432501).
Definition
ChEBI: 8-Dehydrocholesterol is a steroid.
IC 50
Human Endogenous Metabolite
References
[1] C WOLF. Changes in serum sterols of rats treated with 7-dehydrocholesterol-delta 7-reductase inhibitors: comparison to levels in humans with Smith-Lemli-Opitz syndrome.[J]. Journal of Lipid Research, 1996, 37 6: 1325-1333.
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] WILLIAM J. GRIFFITHS . Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients[J]. Journal of Steroid Biochemistry and Molecular Biology, 2017, 169: Pages 77-87. DOI: 10.1016/j.jsbmb.2016.03.018
(3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol Preparation Products And Raw materials
Raw materials
Preparation Products
(3S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol Suppliers
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