TOSUFLOXACIN TOSILATE

Product Name: TOSUFLOXACIN TOSILATE
CAS No.: 100490-36-6
Chemical Name: TOSUFLOXACIN TOSILATE
Synonyms: Ozex;TFLX;a67107;a61827;A-60969;Toskisasin;Aids007807;Aids-007807;abbott61827;108138-46-1 (Deleted)
CBNumber: CB5138403
Molecular Formula: C19H15F3N4O3
Formula Weight: 404.34
MOL File: 100490-36-6.mol

More

Less

TOSUFLOXACIN TOSILATE Property

Boiling point:: 614.4±55.0 °C(Predicted)
Density: 1.558±0.06 g/cm3(Predicted)
pka: 5.79±0.70(Predicted)
InChI: InChI=1S/C19H15F3N4O3/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29)
InChIKey: WUWFMDMBOJLQIV-UHFFFAOYSA-N
SMILES: N1(C2=CC=C(F)C=C2F)C2C(=CC(F)=C(N3CCC(N)C3)N=2)C(=O)C(C(O)=O)=C1
CAS DataBase Reference: 100490-36-6(CAS DataBase Reference)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: T549503
Product name: Tosufloxacin
Packaging: 50mg
Price: $695
Updated: 2021/12/16

TRC

Product number: T549503
Product name: Tosufloxacin
Packaging: 10mg
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004457
Product name: TOSUFLOXACIN
Purity: 95.00%
Packaging: 250MG
Price: $241.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004457
Product name: TOSUFLOXACIN
Purity: 95.00%
Packaging: 1G
Price: $945.95
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18794
Product name: Tosufloxacintosilate
Packaging: 25mg
Price: $1500
Updated: 2021/12/16

More

Less

TOSUFLOXACIN TOSILATE Chemical Properties,Usage,Production

Uses

Tosufloxacin Tosilate (CAS# 100490-36-6) was identified in a Haemophilus influenza clone ST422.

Definition

ChEBI: 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid is a 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 3-aminopyrrolidin-1-yl substituents at positions 1, 6 and 7 respectively. It is a 1,8-naphthyridine derivative, an amino acid, a monocarboxylic acid, an organofluorine compound, an aminopyrrolidine, a tertiary amino compound, a primary amino compound and a quinolone antibiotic. It is a conjugate base of a 1-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5-oxo-5,8-dihydro-1,8-naphthyridin-2-yl]pyrrolidin-3-aminium.

in vivo

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo^[2].

Animal Model:	Male Slc:ICR mice infected with S. aureus^[2]
Dosage:	1.27-2.15 mg/kg
Administration:	Oral gavage; 1.27-2.15 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 1.62 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL.

Animal Model:	Male Slc:ICR mice infected with E. coli^[2]
Dosage:	0.16-0.30 mg/kg
Administration:	Oral gavage; 0.16-0.30 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 0.22 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL.

Animal Model:	Male Slc:ICR mice infected with P. aeruginosa^[2]
Dosage:	7.66-13.39 mg/kg
Administration:	Oral gavage; 7.66-13.39 mg/kg; once
Result:	Showed 50% effective dose (ED₅₀) of 10.13 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.78 μg/mL.

IC 50

Quinolone

TOSUFLOXACIN TOSILATE Preparation Products And Raw materials

Raw materials

2-Chloropyridine-N-oxide p-Toluenesulfonic acid Ethyl fluoroacetate Tosufloxacin Glycine 2,4-Difluoroaniline 3-Aminopyrrolidine Pyrrolidine

Preparation Products

More

Less

TOSUFLOXACIN TOSILATE Suppliers

China 25 Europe 2 Germany 1 Switzerland 2 United Kingdom 6 United States 13 Global 49

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4180
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-025-85560043 17301488900
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9286
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 18351873721
Email: helen.zhang@synzest.com
Country: China
ProdList: 8295
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

guoyungurui

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 10335
Advantage: 58

Henan Chemyou Technology Co., Ltd

Tel: 0372-15803728682 15803728682
Email: hnkmy2023@163.com
Country: China
ProdList: 517
Advantage: 58

Hangzhou Bingochem Co., Ltd.

Tel: 0571-8512-5372
Email: sales@bingochem.com
Country: China
ProdList: 21669
Advantage: 58

Shanghai Aitixi Biotechnology Co., Ltd

Tel: 18721763493
Email: 2493172863@qq.com
Country: China
ProdList: 943
Advantage: 58

Shaanxi Linbang Industrial Co., Ltd

Tel: 17709134430
Email: 2379795542@qq.com
Country: China
ProdList: 4834
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 24727
Advantage: 58

Nanjing Qihui Pharmtehc Co., Ltd.

Tel: --
Fax: --
Email: sales@qhpharm.com
Country: China
ProdList: 110
Advantage: 50

Shanghai PI Chemicals Ltd.

Tel: --
Fax: --
Email: sales@pipharm.com
Country: China
ProdList: 6344
Advantage: 56

Yancheng Foyo Pharm. & Chem. Co., Ltd

Tel: --
Fax: --
Email: tanghua@foyochem.com
Country: China
ProdList: 200
Advantage: 54

Yarong Chemical Development Ltd

Tel: --
Fax: --
Country: China
ProdList: 297
Advantage: 56

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

Shanghai FWD Chemicals Co., Ltd.

Tel: --
Fax: --
Email: sales@fwdchem.com
Country: China
ProdList: 6927
Advantage: 58

More

Less

View Lastest Price from TOSUFLOXACIN TOSILATE manufacturers

Dideu Industries Group Limited

Product: TOSUFLOXACIN TOSILATE 100490-36-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-19

Career Henan Chemical Co

Product: TOSUFLOXACIN TOSILATE 100490-36-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-11

100490-36-6, TOSUFLOXACIN TOSILATERelated Search:

Tosufloxacin Norfloxacin Tosufloxacin tosilate ETHYL7-(3-AMINO-1-PYRROLIDINYL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLATE TOSUFLOXACIN TOSILATE

1,8-naphthyridine-3-carboxylicacid,1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-(

4-difluorophenyl)-6-fluoro-4-oxo-

a61827

a67107

1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-aminopyrrolidin-1-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo- (9CI)

A-60969

Ozex

Toskisasin

7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

7-(3-Aminopyrrolizino)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

TFLX

100490-94-6 (Tosylate)

104051-69-6 (Monohydrate hydrochloride)

107097-79-0 (Monohydrate)

108138-46-1 (Deleted)

7-(3-Amino-1-pyrrolidinyl-1-(2,4-diflurophenyl)-6-fluro-1,4-dihydro-4-oxo-naphthyridine-3-carboxylic acid

Aids007807

Aids-007807

WUWFMDMBOJLQIV-UHFFFAOYSA-N

(+)-7-(3-Amino-1-pyrrolidinyl)-6-fluoro-1-(2，4-difluo-rophenyl)-1，4-dihydrcr-4-oxo-1，8-naphthyridine-3-carboxyli cacid

abbott61827

1,8-Naphthyridine-3-carboxylic acid, 7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-

TOSUFLOXACIN TOSILATE USP/EP/BP

Lactide Impurity 2 (DL-Lactide)

100490-36-6

C19H15F3N4O3SC7H8O3S

C19H15F3N4O3C7H8O3S

C19H15F3N4O3