ChemicalBook > CAS DataBase List > 2,4-DICHLORO-6-FLUOROQUINAZOLINE

2,4-DICHLORO-6-FLUOROQUINAZOLINE

Product Name
2,4-DICHLORO-6-FLUOROQUINAZOLINE
CAS No.
134517-57-0
Chemical Name
2,4-DICHLORO-6-FLUOROQUINAZOLINE
Synonyms
4-dichloro-6-fluoroquinazoline;2,4-Dichloro-6-fluoroquinazolin;2,4-dichloro-6-fluoroquinazoline;Quinazoline, 2,4-dichloro-6-fluoro-;2,4-dichloro-6-fluoroquinazoline 97+%
CBNumber
CB51501961
Molecular Formula
C8H3Cl2FN2
Formula Weight
217.03
MOL File
134517-57-0.mol
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2,4-DICHLORO-6-FLUOROQUINAZOLINE Property

Boiling point:
277.3±22.0 °C(Predicted)
Density 
1.571±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.09±0.30(Predicted)
Appearance
White to yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B419270
Product name
2,4-Dichloro-6-fluoroquinazoline
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B419270
Product name
2,4-Dichloro-6-fluoroquinazoline
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
057314
Product name
2,4-Dichloro-6-fluoroquinazoline
Purity
97%
Packaging
250mg
Price
$38
Updated
2021/12/16
Apolloscientific
Product number
PC502106
Product name
2,4-dichloro-6-fluoroquinazoline
Purity
97+%
Packaging
1g
Price
$71
Updated
2021/12/16
Matrix Scientific
Product number
057314
Product name
2,4-Dichloro-6-fluoroquinazoline
Purity
97%
Packaging
1g
Price
$74
Updated
2021/12/16
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2,4-DICHLORO-6-FLUOROQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

88145-90-8

134517-57-0

(Step 2) Synthesis of 2,4-dichloro-6-fluoroquinazoline: Phosphorus pentachloride (12.5 g, 60.0 mmol) was added to phosphorus trichloride (46.0 mL, 502.5 mmol), followed by the slow addition of 6-fluoroquinazoline-2,4(1H,3H)-dione (3.6 g, 20.0 mmol) under stirring. The reaction mixture was heated to reflux and stirred for 9 hours. After completion of the reaction, the mixture was cooled and the solvent was removed under vacuum. An ice-water mixture (400 mL) was added to the residue and stirring was continued for 0.5 hours. The mixture was extracted with dichloromethane (DCM, 250 mL x 3). The DCM layers were combined, dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, v/v=30/1) to afford the title compound 2,4-dichloro-6-fluoroquinazoline as a white solid (3.735 g, 86.0% yield). m/z MS (ESI, cationic): 216.9 [M + H]+; 1H NMR (CDCl3, 400 MHz) δ ( ppm): 8.03 (dd, J=9.2 Hz, 4.9 Hz, 1H), 7.86 (dd, J=8.1 Hz, 2.7 Hz, 1H), 7.79-7.73 (m, 1H).

References

[1] Patent: WO2017/12502, 2017, A1. Location in patent: Page/Page column 52
[2] Patent: WO2017/88759, 2017, A1. Location in patent: Paragraph 00214
[3] Patent: CN105949203, 2016, A. Location in patent: Paragraph 0179; 0185; 0186
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7717 - 7727
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7855 - 7865

2,4-DICHLORO-6-FLUOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DICHLORO-6-FLUOROQUINAZOLINE Suppliers

China 108 Germany 2 India 1 Switzerland 2 United Kingdom 2 United States 15 Global 130
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View Lastest Price from 2,4-DICHLORO-6-FLUOROQUINAZOLINE manufacturers

Career Henan Chemical Co
Product
2,4-DICHLORO-6-FLUOROQUINAZOLINE 134517-57-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-25

134517-57-0, 2,4-DICHLORO-6-FLUOROQUINAZOLINERelated Search:

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  • 134517-57-0