5-CHLORO-1H-INDOLE-2-CARBALDEHYDE

Product Name: 5-CHLORO-1H-INDOLE-2-CARBALDEHYDE
CAS No.: 53590-49-1
Chemical Name: 5-CHLORO-1H-INDOLE-2-CARBALDEHYDE
Synonyms: 5-chloro-indole-2-carbaldehyde;5-Chloroindole-2-carboxaldehyde;5-CHLORO-1H-INDOLE-2-CARBALDEHYDE;1H-Indole-2-carboxaldehyde, 5-chloro-;5-Chloro-1H-indole-2-carbaldehyde ,97%
CBNumber: CB5166145
Molecular Formula: C9H6ClNO
Formula Weight: 179.6
MOL File: 53590-49-1.mol

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5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Property

Melting point:: 204-206 °C
Boiling point:: 373.4±22.0 °C(Predicted)
Density: 1.431±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 14.14±0.30(Predicted)
Appearance: Off-white to brown Solid

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Safety

Hazard Codes: Xi
Risk Statements: 36-20/21/22
Safety Statements: 26-36/37
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C588215
Product name: 5-Chloro-1H-indole-2-carbaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C588215
Product name: 5-Chloro-1H-indole-2-carbaldehyde
Packaging: 100mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: Z2968
Product name: 5-Chloroindole-2-carboxaldehyde
Packaging: 250mg
Price: $172
Updated: 2021/12/16

Matrix Scientific

Product number: 016207
Product name: 5-Chloro-1H-indole-2-carbaldehyde
Packaging: 500mg
Price: $184
Updated: 2021/12/16

Apolloscientific

Product number: OR930619
Product name: 5-Chloro-1H-indole-2-carbaldehyde
Purity: 95%
Packaging: 250mg
Price: $215
Updated: 2021/12/16

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5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Synthesis

53590-47-9

53590-49-1

General procedure for the synthesis of 5-chloro-1H-indole-2-carboxaldehyde from (5-chloro-1H-indol-2-yl)methanol: (5-chloro-1H-indol-2-yl)methanol (1 eq.) was dissolved in tetrahydrofuran (THF, 0.5 M), manganese dioxide (3 eq.) was added, the reaction was stirred for 1.5 hr. at room temperature, and the progress of the reaction was monitored by thin layer chromatography (TLC) until the complete conversion of the feedstock. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad, the filtrate was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give the crude 5-chloro-1H-indole-2-carbaldehyde in 82% yield.

References

[1] Synlett, 2007, # 11, p. 1707 - 1710
[2] Chemical Communications, 2013, vol. 49, # 28, p. 2894 - 2896
[3] Patent: US2008/9485, 2008, A1. Location in patent: Page/Page column 41
[4] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 561 - 577
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 6, p. 1889 - 1900

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

4-Chlorophenylhydrazine hydrochloride Ethanol Ethyl pyruvate Manganese dioxide Polyphosphoric acid Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

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5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Suppliers

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53590-49-1, 5-CHLORO-1H-INDOLE-2-CARBALDEHYDERelated Search:

5-Chloroindole-2-carboxylic acid Ethyl 5-chloro-2-indolecarboxylate 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE 5-CHLORO-N-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-1H-INDOLE-2-CARBOXAMIDE Ethyl 3-amino-5-chloro-1H-indole-2-carboxylate 5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER ETHYL 5-CHLORO-3-METHYL-1H-INDOLE-2-CARBOXYLATE 6-CHLORO-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXAMIDE 5-CHLORO-3-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID 5,7-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID 6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one ETHYL 5-CHLORO-3-PHENYL-1H-INDOLE-2-CARBOXYLATE AKOS JY2083294 3-(2-AMINOETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID 5-chloro-3-phenylthioindole-2-carboxamide 3-ACETYLAMINO-5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID 5-CHLORO-1-(4-NITROBENZYL)-3-PHENYL-1H-INDOLE-2-CARBOXAMIDE 5-CHLORO-3-PHENYL-1H-INDOLE-2-CARBOXAMIDE

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE

5-chloro-indole-2-carbaldehyde

1H-Indole-2-carboxaldehyde, 5-chloro-

5-Chloro-1H-indole-2-carbaldehyde ,97%

5-Chloroindole-2-carboxaldehyde

53590-49-1