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Merck SIP Agonist

Product Name
Merck SIP Agonist
CAS No.
635701-59-6
Chemical Name
Merck SIP Agonist
Synonyms
CS-126;CAY10734;Merck SIP Agonist;SHQNRSGKLNMHOS-UHFFFAOYSA-N;1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid;butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid;1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid;1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid;3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
CBNumber
CB51872315
Molecular Formula
C23H25N3O3
Formula Weight
391.46
MOL File
635701-59-6.mol
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Merck SIP Agonist Property

Boiling point:
565.9±60.0 °C(Predicted)
Density 
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: Partially soluble
form 
A crystalline solid
pka
2.66±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
10mg
Price
$243
Updated
2024/03/01
AK Scientific
Product number
7502CR
Product name
MerckSIPAgonist
Packaging
5mg
Price
$252
Updated
2021/12/16
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Merck SIP Agonist Chemical Properties,Usage,Production

Description

CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; ).

References

[1] ZHEN LI. Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3[J]. Journal of Medicinal Chemistry, 2005, 48 20: 6169-6173. DOI: 10.1021/jm0503244

Merck SIP Agonist Preparation Products And Raw materials

Raw materials

Preparation Products

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Merck SIP Agonist Suppliers

China 22 United States 8 Global 30
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7181
Advantage
55
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
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58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
ZhengZhou Edward Biology Co.,Ltd
Tel
13298105281
Email
1522334715@qq.com
Country
China
ProdList
7507
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
hanfangpharma@126.com; 18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29965
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
Guangzhou Biopark Technology Co., Ltd.
Tel
020-83808789
Country
CHINA
ProdList
179
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58
Aoki Biotechnology (Shenzhen) Co., Ltd.
Tel
18566777408
Country
CHINA
ProdList
156
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58
Guangzhou Chuangze Biotechnology Co., Ltd.
Tel
18312220236
Country
CHINA
ProdList
178
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Biorbyt Ltd.
Tel
--
Fax
--
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info@biorbyt.com
Country
CHINA
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6482
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Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
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58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
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58
Taizhou Crene Chempharm Co., Ltd.
Tel
--
Fax
--
Email
sales@pharm-intermediates.com
Country
China
ProdList
596
Advantage
35
LONGRE Pharmaceuticals Co., Ltd.
Tel
--
Fax
--
Email
sales@longrepharm.com
Country
China
ProdList
169
Advantage
0

635701-59-6, Merck SIP AgonistRelated Search:


  • Merck SIP Agonist
  • CS-126
  • CAY10734
  • butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid
  • 1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
  • SHQNRSGKLNMHOS-UHFFFAOYSA-N
  • 3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
  • 1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid
  • 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid
  • 635701-59-6