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Merck SIP Agonist

Product Name
Merck SIP Agonist
CAS No.
635701-59-6
Chemical Name
Merck SIP Agonist
Synonyms
CS-126;CAY10734;Merck SIP Agonist;SHQNRSGKLNMHOS-UHFFFAOYSA-N;1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid;butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid;1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid;1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid;3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
CBNumber
CB51872315
Molecular Formula
C23H25N3O3
Formula Weight
391.46
MOL File
635701-59-6.mol
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Merck SIP Agonist Property

Boiling point:
565.9±60.0 °C(Predicted)
Density 
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: Partially soluble
form 
A crystalline solid
pka
2.66±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
10007833
Product name
CAY10734
Packaging
10mg
Price
$243
Updated
2024/03/01
AK Scientific
Product number
7502CR
Product name
MerckSIPAgonist
Packaging
5mg
Price
$252
Updated
2021/12/16
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Merck SIP Agonist Chemical Properties,Usage,Production

Description

CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; ).

References

[1] ZHEN LI. Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3[J]. Journal of Medicinal Chemistry, 2005, 48 20: 6169-6173. DOI: 10.1021/jm0503244

Merck SIP Agonist Preparation Products And Raw materials

Raw materials

Preparation Products

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Merck SIP Agonist Suppliers

China 22 United States 8 Global 30
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0

635701-59-6, Merck SIP AgonistRelated Search:


  • Merck SIP Agonist
  • CS-126
  • CAY10734
  • butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid
  • 1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
  • SHQNRSGKLNMHOS-UHFFFAOYSA-N
  • 3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
  • 1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid
  • 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid
  • 635701-59-6