Methyl 3-pyrrolidinecarboxylate
Application- Product Name
- Methyl 3-pyrrolidinecarboxylate
- CAS No.
- 98548-90-4
- Chemical Name
- Methyl 3-pyrrolidinecarboxylate
- Synonyms
- Zinc04202763;Zinc04202762;METHYL-PROLINATE;METHYL 3-PYRROLIDINECARBOXYLATE;METHYL PYRROLIDINE-3-CARBOXYLATE;methyl pyrrolidine-3-carboxylate.HCl;3-Pyrrolidinecarboxylic acid methyl ester;NUR NOCH ALS AST63827 !! METHYL-PROLINATE;PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER;3-Pyrrolidinecarboxylic acid, methyl ester (6CI, 9CI, ACI)
- CBNumber
- CB5193815
- Molecular Formula
- C6H11NO2
- Formula Weight
- 129.16
- MOL File
- 98548-90-4.mol
Methyl 3-pyrrolidinecarboxylate Property
- Boiling point:
- 92 °C(Press: 17 Torr)
- Density
- 1.055±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 9.42±0.10(Predicted)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
N-Bromosuccinimide Price
- Product number
- M218805
- Product name
- MethylPyrrolidine-3-carboxylate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 144338
- Product name
- Methyl 3-pyrrolidinecarboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $533
- Updated
- 2021/12/16
- Product number
- CHM0032033
- Product name
- PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
- Product number
- CHM0032033
- Product name
- PYRROLIDINE-3-CARBOXYLIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1473.14
- Updated
- 2021/12/16
- Product number
- 144338
- Product name
- Methyl 3-pyrrolidinecarboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $1599
- Updated
- 2021/12/16
Methyl 3-pyrrolidinecarboxylate Chemical Properties,Usage,Production
Application
Methyl 3-pyrrolidinecarboxylate can be used as a pharmaceutical synthesis intermediate. It can be prepared from benzyl-trimethylsilylmethylamine as a reactant or from methyl 1-benzyl-2-oxopyrrolidine-4-carboxylic acid as a reactant.
Synthesis
Step 1: Benzyl-trimethylsilylmethylamine (100 g, 517 mmol, 1 eq.) was loaded into a 1 L jacketed reactor, followed by 400 mL of THF. The reaction temperature was set to 15 ??C and 37% aqueous formaldehyde (53 mL, 647 mmol, 1.25 eq.) was added dropwise over ~10 min, keeping the temperature <30 ??C.
Step 2: In a separate reactor, 400 mL of THF (Tj=25°C) was charged, followed by the addition of N-methylmorpholine (2.85 mL, 26 mmol, 0.05 eq.), trifluoroacetic acid (TFA) (1 mL, 13 mmol, 0.025) eq.) and methyl acrylate (56.5 mL, 621 mmol, 1.2 eq. ). The solution was heated to 50-55 ??C and the solution from Reactor A was added dropwise over about 50 min. About 30 min after the end of the addition (completion of the reaction was judged by IPC), the reactor was cooled to room temperature and the solution was concentrated to about 500 mL. 250 mL of heptane was added, the organic phase was washed twice with 250 mL of water, the organic phase was dried over MgSO4, and the reaction was concentrated under reduced pressure (as low as 10-20 mbar, 45 ??C) to give 108 g of the crude product, N-Bn-pyrrolidine (90% yield) .
Step 3: 1 kg of N-Bn-pyrrolidine (4414 mmol, 1 eq.) was dissolved in 10 L of methanol and hydrogenated over 101 g of Pd/C (95 mmol Pd, 0.02 eq.) at atmospheric pressure. Upon completion of the reaction, the catalyst was filtered and the solution was concentrated to about 10 L. Methyl 3-pyrrolidinecarboxylate was obtained by adding 2 L of methanol and distilling at a constant volume.
Methyl 3-pyrrolidinecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-pyrrolidinecarboxylate Suppliers
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 025-83697070 13913916777;
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15724
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
View Lastest Price from Methyl 3-pyrrolidinecarboxylate manufacturers
- Product
- Methyl 3-pyrrolidinecarboxylate 98548-90-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- Methyl 3-pyrrolidinecarboxylate 98548-90-4
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31