Description Health Benefits Side effects Uses
ChemicalBook > CAS DataBase List > 4-Hydroxyphenethyl alcohol

4-Hydroxyphenethyl alcohol

Description Health Benefits Side effects Uses
Product Name
4-Hydroxyphenethyl alcohol
CAS No.
501-94-0
Chemical Name
4-Hydroxyphenethyl alcohol
Synonyms
TYROSOL;4-(2-HYDROXYETHYL)PHENOL;Benzeneethanol, 4-hydroxy-;2-(4-HYDROXYPHENYL)ETHANOL;4-Hydroxyphenylethanol;P-HYDROXYPHENYLETHANOL;p-Hydroxyphenylethyl alcohol;4-Hydroxyphenyl-2-ethanol;PHEP;p-Tyrosol
CBNumber
CB5227235
Molecular Formula
C8H10O2
Formula Weight
138.16
MOL File
501-94-0.mol
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4-Hydroxyphenethyl alcohol Property

Melting point:
89-92 °C(lit.)
Boiling point:
195°C (18 mmHg)
Density 
1.0742 (rough estimate)
refractive index 
1.5590 (estimate)
Flash point:
139°C/1mm
storage temp. 
Store below +30°C.
solubility 
124g/l
pka
10.17±0.13(Predicted)
form 
Crystals or Crystalline Powder
color 
Off-white to light beige
Odor
at 100.00 %. mild sweet floral fruity
Odor Type
floral
Water Solubility 
slightly soluble
BRN 
1859884
InChIKey
YCCILVSKPBXVIP-UHFFFAOYSA-N
LogP
0.851 (est)
CAS DataBase Reference
501-94-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneethanol, 4-hydroxy-(501-94-0)
EPA Substance Registry System
4-Hydroxybenzeneethanol (501-94-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-24/25-36
WGK Germany 
3
F 
10
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29072900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR9188
Product name
Metoprolol EP Impurity G
Purity
certified reference material, <I>Trace</I><B>CERT</B><SUP>&#174;</SUP>, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Packaging
1 unit
Price
$538
Updated
2025/07/31
Sigma-Aldrich
Product number
79058
Product name
2-(4-Hydroxyphenyl)ethanol
Purity
analytical standard
Packaging
100mg
Price
$29.5
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL80166
Product name
Tyrosol
Purity
phyproof? Reference Substance
Packaging
20MG
Price
$381
Updated
2025/07/31
Sigma-Aldrich
Product number
79058
Product name
2-(4-Hydroxyphenyl)ethanol
Purity
analytical standard
Packaging
500mg
Price
$97.9
Updated
2025/07/31
Sigma-Aldrich
Product number
188255
Product name
2-(4-Hydroxyphenyl)ethanol
Purity
98%
Packaging
25g
Price
$106.4
Updated
2025/07/31
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4-Hydroxyphenethyl alcohol Chemical Properties,Usage,Production

Description

Phenylalanine is an amino acid, which are the building blocks of proteins in your body. This molecule exists in two forms or arrangements: L-phenylalanine and D-phenylalanine. They’re nearly identical but have a slightly different molecular structure. The L-form is found in foods and used to produce proteins in your body, while the D-form can be synthesized for use in certain medical applications . Your body is unable to produce enough L-phenylalanine on its own, so it’s considered an essential amino acid that must be obtained through your diet. It’s found in a wide variety of foods — both plant and animal sources. In addition to its role in protein production, phenylalanine is used to make other important molecules in your body, several of which send signals between different parts of your body. Phenylalanine has been studied as a treatment for several medical conditions, including skin disorders, depression and pain. However, it can be dangerous for people with the genetic disorder phenylketonuria (PKU).

Health Benefits

Phenylalanine can be used to produce the molecule dopamine. Dopamine malfunction in the brain is associated with some forms of depression . One small 12-person study showed a possible benefit of a mixture of the D- and L-forms of this amino acid for treating depression, with 2/3 of patients showing improvement . However, there is minimal other support for phenylalanine’s effects on depression, and most studies have not found clear benefits. In addition to vitiligo and depression, phenylalanine has been studied for potential effects on:

Pain: The D-form of phenylalanine may contribute to pain relief in some instances, though study results are mixed .

Alcohol withdrawal: A small amount of research indicates that this amino acid, along with other amino acids, may help alleviate symptoms of alcohol withdrawal.

Parkinson’s disease: Very limited evidence suggests that phenylalanine may be beneficial in treating Parkinson’s disease, but more studies are needed .

ADHD: Currently, research does not indicate benefits of this amino acid for the treatment of attention deficit hyperactivity disorder (ADHD) .

Side effects

Phenylalanine is found in many protein-containing foods and is “generally recognized as safe” by the Food and Drug Administration (FDA) (27). The amount of this amino acid found in foods should not pose a risk for otherwise healthy individuals. What’s more, few or no side effects are generally observed at supplement doses of 23–45 mg per pound (50–100 mg per kg) of body weight (9Trusted Source, 13Trusted Source). However, it may be best for pregnant women to avoid taking phenylalanine supplements.

Uses

L-phenylalanine (LPA) serves as a building block for the various proteins that are produced in the body. LPA can be converted to L-tyrosine (another amino acid ) and subsequently to L-dopa, norepinephrine, and epinephrine . LPA can also be converted (through a separate pathway) to phenylethylamine, a substance that occurs naturally in the brain and appears to elevate mood.

Chemical Properties

off-white to light beige crystals or crystalline

Uses

Tyrosol (Metoprolol EP Impurity G) is a phenolic antioxidant.

Uses

Phenolic antioxidant.

Definition

ChEBI: A phenol substituted at position 4 by a 2-hydroxyethyl group.

General Description

2-(4-Hydroxyphenyl)ethanol is a phenolic alcohol commonly present in olive mill wastewater.

Biochem/physiol Actions

Antioxidant found in olive oil.

Synthesis

156-38-7

501-94-0

Step 1: Synthesis of 4-(2-hydroxyethyl)phenol. Following the literature method [54], 2-(4-hydroxyphenyl)acetic acid (760 mg, 5 mmol) was dissolved in ethanol (20 mL) and sulfuric acid (27 μL, 0.5 mmol) was added. The reaction mixture was heated to reflux for 3 h. The reaction progress was monitored by TLC. After completion of the reaction, the solvent was removed under reduced pressure and the crude product was dissolved in anhydrous THF (20 mL). LiAlH4 (228 mg, 6 mmol) was slowly added at 0 °C, followed by gradual warming of the mixture to room temperature and stirring for 12 hours. Upon completion of the reaction (monitored by TLC), the reaction solution was cooled to 0 °C, quenched with Na2SO4-10H2O solid and filtered through Celite. The solvent was removed under reduced pressure and the residue was diluted with water (20 mL) and extracted with ethyl acetate (3 x 20 mL). The organic layers were combined, dried over MgSO4 and concentrated in vacuum. The crude product was purified by fast chromatography (eluent: hexane/ethyl acetate, 5:1→2:1) to afford 4-(2-hydroxyethyl)phenol as an off-white solid (600 mg, 87% yield). rf (hexane/ethyl acetate 2:1): 0.30. 1H NMR (400 MHz, CDCl3): δ 7.10 (2H, dd, J = 2.0, 6.4 Hz), 6.78 (2H, dd, J = 2.0, 6.4 Hz), 4.83 (1H, br.s), 3.83 (2H, dd, J = 6.4, 15.0 Hz), 2.80 (2H, t, J = 6.4 Hz).13C NMR (100 MHz, CDCl3): δ 154.4, 130.6, 130.3, 115.6, 64.0, 38.4. The spectral data are in agreement with literature reports [54].

References

[1] Tetrahedron Letters, 2008, vol. 49, # 20, p. 3260 - 3263
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 4, p. 1063 - 1066
[3] Journal of the American Chemical Society, 2001, vol. 123, # 35, p. 8618 - 8619
[4] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 22, p. 5852 - 5869
[5] Tetrahedron Letters, 2000, vol. 41, # 33, p. 6415 - 6418

4-Hydroxyphenethyl alcohol Preparation Products And Raw materials

Raw materials

Glyoxal 4'-Hydroxyacetophenone

Preparation Products

2-(4-BENZYLOXYPHENYL)ETHANOL
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View Lastest Price from 4-Hydroxyphenethyl alcohol manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
4-Hydroxyphenethyl alcohol HL 501-94-0
Price
US $19.00/KG
Min. Order
1KG
Purity
99
Supply Ability
20000
Release date
2025-08-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Hydroxyphenethyl alcohol 501-94-0
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-12-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Hydroxyphenethyl alcohol 501-94-0
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-10-25

501-94-0, 4-Hydroxyphenethyl alcoholRelated Search:

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