Methyl 3-bromo-4-hydroxybenzoate
- Product Name
- Methyl 3-bromo-4-hydroxybenzoate
- CAS No.
- 29415-97-2
- Chemical Name
- Methyl 3-bromo-4-hydroxybenzoate
- Synonyms
- EOS-61539;Methyl 3-bromo;Methyl 3-bromo-4-hydroxybenzoa;Methyl3-bromo-4-hydroxybenzoate,98%;Methyl 3-bromo-4-hydroxybenzoayl)carbaMate;Benzoic acid, 3-bromo-4-hydroxy-, methyl ester
- CBNumber
- CB52488278
- Molecular Formula
- C8H7BrO3
- Formula Weight
- 231.04
- MOL File
- 29415-97-2.mol
Methyl 3-bromo-4-hydroxybenzoate Property
- Melting point:
- 108-110℃
- Boiling point:
- 283.1±20.0 °C(Predicted)
- Density
- 1.627±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- 6.82±0.18(Predicted)
- form
- solid
- color
- White
- InChI
- InChI=1S/C8H7BrO3/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4,10H,1H3
- InChIKey
- RKUNSPWAQIUGEZ-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(O)C(Br)=C1
Safety
- RIDADR
- UN2811
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M296110
- Product name
- Methyl3-bromo-4-hydroxybenzoate
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- M296110
- Product name
- Methyl3-bromo-4-hydroxybenzoate
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 455177
- Product name
- Methyl 3-bromo-4-hydroxybenzoate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- J94780
- Product name
- Methyl3-bromo-4-hydroxybenzoate
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- J94780
- Product name
- Methyl3-bromo-4-hydroxybenzoate
- Packaging
- 5g
- Price
- $20
- Updated
- 2021/12/16
Methyl 3-bromo-4-hydroxybenzoate Chemical Properties,Usage,Production
Uses
A reactant used in the preparation of selective inhibitors. In unsymmetrical Ullman reaction between methyl 5bromovanillate (II) and methyl 3-bromo-4-hydroxybenzoate (III) yielded all the three possible dicarbomethoxy-dibenzo-pdioxms which were separated by repeated chromatography over silica gel. A phosphorus- and bromine-containing bifunctional monomer has been prepared from bis(chloromethyl)methylphosphine oxide and the sodium salt of methyl 3-bromo-4-hydroxybenzoate.
Synthesis
67-56-1
14348-41-5
29415-97-2
The general procedure for the synthesis of methyl 3-bromo-4-hydroxybenzoate from methanol and 3-bromo-4-hydroxybenzoic acid is as follows: 1. Preparation of intermediate T3.1 (methyl 3-bromo-4-hydroxybenzoate): - Under stirring conditions, 3-bromo-4-hydroxybenzoic acid (50.0 g, 231 mmol) was dissolved in methanol (300 mL). - To the above solution was slowly added cold sulfuric acid solution (2.50 mL, 47 mmol). - The reaction mixture was heated to 80 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). - After 16.5 h of reaction, the solvent was removed by distillation under reduced pressure. - The reaction mixture was diluted with ethyl acetate (EtOAc). - The organic phase was sequentially washed twice with saturated aqueous sodium bicarbonate (NaHCO3), once with brine and then dried with anhydrous sodium sulfate. - After filtration, the organic solvent was removed by distillation under reduced pressure to give the intermediate T3.1 as a white solid in 100% yield, which can be used in the next reaction without further purification.
References
[1] Patent: WO2010/45258, 2010, A2. Location in patent: Page/Page column 119
[2] Patent: WO2009/111056, 2009, A1. Location in patent: Page/Page column 103; 141
[3] Patent: WO2017/36404, 2017, A1. Location in patent: Paragraph 57; 58
[4] Patent: EP2380890, 2011, A1. Location in patent: Page/Page column 35
[5] Macromolecules, 2003, vol. 36, # 12, p. 4328 - 4336
Methyl 3-bromo-4-hydroxybenzoate Preparation Products And Raw materials
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View Lastest Price from Methyl 3-bromo-4-hydroxybenzoate manufacturers
- Product
- Methyl 3-bromo-4-hydroxybenzoa 29415-97-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2025-05-08
- Product
- Methyl 3-bromo-4-hydroxybenzoa 29415-97-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2025-04-02
- Product
- Methyl 3-bromo-4-hydroxybenzoate 29415-97-2
- Price
- US $1.00-1.00/KG
- Min. Order
- 25KG
- Purity
- 99.0%
- Supply Ability
- 3000KG/th
- Release date
- 2023-06-13