1H-Indazole-3-carboxylic acid, 6-bromo-1-methyl-, methyl ester
- Product Name
- 1H-Indazole-3-carboxylic acid, 6-bromo-1-methyl-, methyl ester
- CAS No.
- 946427-77-6
- Chemical Name
- 1H-Indazole-3-carboxylic acid, 6-bromo-1-methyl-, methyl ester
- Synonyms
- Methyl 6-bromo-1-methyl-1...;Methyl 6-bromo-1-methylindazole-3-carboxylate;Methyl 6-bromo-1-methyl-1H-indazole-3-carboxyl;Methyl 6-broMo-1-Methyl-1H-indazole-3-carboxylate;6-bromo-1-methyl-1H-indazole-3-carboxylic acid methyl ester;1H-Indazole-3-carboxylic acid, 6-bromo-1-methyl-, methyl ester
- CBNumber
- CB52525137
- Molecular Formula
- C10H9BrN2O2
- Formula Weight
- 269.09
- MOL File
- 946427-77-6.mol
1H-Indazole-3-carboxylic acid, 6-bromo-1-methyl-, methyl ester Property
- Boiling point:
- 366.7±22.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.74±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0048947
- Product name
- Methyl6-bromo-1-methyl-1H-indazole-3-carboxylate
- Packaging
- 100mg
- Price
- $214
- Updated
- 2021/12/16
- Product number
- CS-0048947
- Product name
- Methyl6-bromo-1-methyl-1H-indazole-3-carboxylate
- Packaging
- 250mg
- Price
- $357
- Updated
- 2021/12/16
- Product number
- HCH0419465
- Product name
- METHYL-6-BROMO-1-METHYL-1H-INDAZOLE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $455.03
- Updated
- 2021/12/16
- Product number
- 4H58-9-0V
- Product name
- Methyl 6-bromo-1-methyl-1H-indazole-3-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- 068469
- Product name
- Methyl 6-bromo-1-methyl-1H-indazole-3-carboxylate
- Purity
- >95%
- Packaging
- 250mg
- Price
- $700
- Updated
- 2021/12/16
1H-Indazole-3-carboxylic acid, 6-bromo-1-methyl-, methyl ester Chemical Properties,Usage,Production
Synthesis
885278-42-2
74-88-4
946427-77-6
Intermediate Preparation 411B; Methyl 6-bromo-1-methyl-1H-indazole-3-carboxylate; To a suspension of methyl 6-bromo-1H-indazole-3-carboxylate (0.50 g, 1.96 mmol) and potassium carbonate (1.28 g, 9.29 mmol) in acetonitrile (15 mL) was added methiodine (1.31 g, 9.29 mmol). The reaction mixture was stirred at room temperature for 15 hours. After completion of the reaction, the solvent was removed under vacuum and the residue was diluted with water (15 mL) and extracted with ethyl acetate (3 x 10 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography using 8:2 hexane/ethyl acetate as eluent to afford 0.35 g (70% yield) of methyl 6-bromo-1-methylindazole-3-carboxylate as an off-white solid.1H NMR (400 MHz, CDCl3) δ 4.03 (s, 3H), 4.14 (s, 3H), 7.42 (dd, J = 8.4, 1.2 Hz, 1H), 7.66 (s, 1H), 8.08 (d, J = 8.8 Hz, 1H).
References
[1] Patent: WO2009/12125, 2009, A1. Location in patent: Page/Page column 38
[2] Patent: WO2011/20615, 2011, A1. Location in patent: Page/Page column 85; 86
[3] Patent: WO2018/177781, 2018, A1. Location in patent: Page/Page column 82-83
1H-Indazole-3-carboxylic acid, 6-bromo-1-methyl-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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