CAY10595

Product Name: CAY10595
CAS No.: 916047-16-0
Chemical Name: CAY10595
Synonyms: CAY10595;CAY10595,CAY-10595;CAY10595 Exclusive;IXKFWNVFUXXEFY-UHFFFAOYSA-N;Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-
CBNumber: CB52590436
Molecular Formula: C20H13Cl2FN2O5
Formula Weight: 451.23
MOL File: 916047-16-0.mol

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CAY10595 Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.5 mg/ml; Ethanol: 25 mg/ml
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10012553
Product name: CAY10595
Purity: ≥97%
Packaging: 1mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 10012553
Product name: CAY10595
Purity: ≥97%
Packaging: 5mg
Price: $291
Updated: 2024/03/01

Cayman Chemical

Product number: 10012553
Product name: CAY10595
Purity: ≥97%
Packaging: 10mg
Price: $516
Updated: 2024/03/01

AK Scientific

Product number: 1879CW
Product name: 2-[5-Chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]aceticacid
Packaging: 10mg
Price: $672
Updated: 2021/12/16

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CAY10595 Chemical Properties,Usage,Production

Description

The biological effects of prostaglandin D₂ (PGD₂) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP₁ and CRTH2/DP₂. In humans, CRTH2/DP₂ is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD₂.¹ CAY10595, as a racemic mixture, is a potent CRTH2/DP₂ receptor antagonist that binds to the human receptor with a K_i value of 10 nM.² The R enantiomer of CAY10595 is significantly more potent exhibiting K_i values of 5.3 and 5 nM at the human and murine CRTH2/DP₂ receptor, respectively. The R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD₂ with an IC₅₀ value of 7.3 nM.²

References

1. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D₂ selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001).
2. Crosignani, S., Page, P., Missotten, M., et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP₂) receptor antagonists for the treatment of allergic inflammatory diseases J. Med. Chem. 51,2227-2243(2008).

CAY10595 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10595 Suppliers

China 24 United States 4 Global 28

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Chongqing Chemieliva Pharmaceutical Co., Ltd.

Tel: 023-67770219
Fax: +86 (23) 6777-0220
Email: jessica.hu@chemieliva.com
Country: China
ProdList: 1450
Advantage: 60

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1990
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
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cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10011
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
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916047-16-0, CAY10595Related Search:

CAY10595

CAY10595 Exclusive

IXKFWNVFUXXEFY-UHFFFAOYSA-N

Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-

CAY10595,CAY-10595

916047-16-0