ChemicalBook > CAS DataBase List > CGP 48664A

CGP 48664A

Product Name: CGP 48664A
CAS No.: 138794-73-7
Chemical Name: CGP 48664A
Synonyms: CGP 48664A;Sardomozide HCl;Metformin Impurity 55;CGP 48664 dihydrochloride;Sardomozide dihydrochloride;Sardomozide (hydrochloride);Sardomozide HCl (SAM-486A or CGP-48664);Sardomozide dihydrochloride, 10 mM in DMSO;CGP 48664 dihydrochloride|||Sardomozide dihydrochloride;2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride
CBNumber: CB52602487
Molecular Formula: C11H15ClN6
Formula Weight: 266.73
MOL File: 138794-73-7.mol

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CGP 48664A Property

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:25.0(Max Conc. mg/mL);82.46(Max Conc. mM)
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3185
Product name: CGP 48664 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $161
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3185
Product name: CGP 48664 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $517
Updated: 2025/07/31

TRC

Product number: C291765
Product name: CGP48664A
Packaging: 5mg
Price: $205
Updated: 2021/12/16

TRC

Product number: C291765
Product name: CGP48664A
Packaging: 1mg
Price: $65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002668
Product name: (E)-1-((DIAMINOMETHYLENE)HYDRAZONO)-2,3-DIHYDRO-1H-INDENE-4-CARBOXIMIDAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $502.66
Updated: 2021/12/16

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CGP 48664A Chemical Properties,Usage,Production

Uses

CGP 48664A is polyamine synthesis inhibitor. It can be used in biological study and therapeutic use. Discovered antiparasitic drugs may influence spermidine/spermine N-1 acetyl transferase associated with polyamine pathway.

Biological Activity

CGP 48664 (SAM486A; Sardomozide) is a polyamine (PA) biosynthesis inhibitor (73% and 97% downregulation of murine leukemia L1210 cellular spermidine and spermine, respectively, by 0.5 μM Sardomozide in 4 days) th at targets the rate-limiting enzyme S-adenosylmethionine decarboxylase (AdoMetDC, SAMDC, AMD1) in a potent (IC50 = 5 nM against r at AMD1) and selective manner with little or no inhibitory efficacy toward diamine oxidase or ornithine decarboxylase (IC50 = 18 μM and >50 μM against r at DAO and ODC, respectively). CGP 48664 effectively inhibits the proliferation of murine (GI50 = 0.5 μM against L1210 in 4 days) and human cancer cell lines in cultures (GI50 from 0.26 to 0.6 μM in 5 days; GI50 = 0.8 μM against human melanoma SK MEL-24 in 10 days) and suppresses the growth of murine and human tumor xenografts in mice in vivo (ED50 ≤0.5 mg/kg i.p.). CGP 48664 (Sardomozide) potently inhibits growth of PFA ependymoma cells.

CGP 48664A Preparation Products And Raw materials

Raw materials

Preparation Products

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138794-73-7, CGP 48664ARelated Search:

CGP 48664A

Sardomozide HCl

Sardomozide dihydrochloride

2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride

Sardomozide HCl (SAM-486A or CGP-48664)

Sardomozide (hydrochloride)

CGP 48664 dihydrochloride|||Sardomozide dihydrochloride

Sardomozide dihydrochloride, 10 mM in DMSO

CGP 48664 dihydrochloride

Metformin Impurity 55

138794-73-7