CGP 48664A

CGP 48664A Property

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO:25.0(Max Conc. mg/mL);82.46(Max Conc. mM)

form 

A solid

color 

White to off-white

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

CGP 48664A Chemical Properties,Usage,Production

Uses

CGP 48664A is polyamine synthesis inhibitor. It can be used in biological study and therapeutic use. Discovered antiparasitic drugs may influence spermidine/spermine N-1 acetyl transferase associated with polyamine pathway.

Biological Activity

CGP 48664 (SAM486A; Sardomozide) is a polyamine (PA) biosynthesis inhibitor (73% and 97% downregulation of murine leukemia L1210 cellular spermidine and spermine, respectively, by 0.5 μM Sardomozide in 4 days) th at targets the rate-limiting enzyme S-adenosylmethionine decarboxylase (AdoMetDC, SAMDC, AMD1) in a potent (IC50 = 5 nM against r at AMD1) and selective manner with little or no inhibitory efficacy toward diamine oxidase or ornithine decarboxylase (IC50 = 18 μM and >50 μM against r at DAO and ODC, respectively). CGP 48664 effectively inhibits the proliferation of murine (GI50 = 0.5 μM against L1210 in 4 days) and human cancer cell lines in cultures (GI50 from 0.26 to 0.6 μM in 5 days; GI50 = 0.8 μM against human melanoma SK MEL-24 in 10 days) and suppresses the growth of murine and human tumor xenografts in mice in vivo (ED50 ≤0.5 mg/kg i.p.). CGP 48664 (Sardomozide) potently inhibits growth of PFA ependymoma cells.