ChemicalBook > CAS DataBase List > 4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride
4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride
- Product Name
- 4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride
- CAS No.
- 142715-48-8
- Chemical Name
- 4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride
- Synonyms
- CP-100356 Monohydrochloride;CP100356 hydrochloride,CP 100356 hydrochloride;4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride
- CBNumber
- CB52620898
- Molecular Formula
- C31H37ClN4O6
- Formula Weight
- 597.10168
- MOL File
- 142715-48-8.mol
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4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >5mg/mL
- form
- powder
- color
- white to off-white
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PZ0171
- Product name
- CP-100356 monohydrochloride
- Purity
- >98% (HPLC)
- Packaging
- 5mg
- Price
- $147
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- PZ0171
- Product name
- CP-100356 monohydrochloride
- Purity
- >98% (HPLC)
- Packaging
- 25mg
- Price
- $547
- Updated
- 2024/03/01
TRC
- Product number
- C781250
- Product name
- CP-100356Hydrochloride
- Packaging
- 10mg
- Price
- $775
- Updated
- 2021/12/16
TRC
- Product number
- C781250
- Product name
- CP-100356Hydrochloride
- Packaging
- 1mg
- Price
- $125
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0000835
- Product name
- CP-100356 HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2055.9
- Updated
- 2021/12/16
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4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-White to Light Tan Solid
Uses
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).
in vivo
CP-100356 (6-24 mg/kg; p.o.) increases the systemic exposure of Fexofenadine (36- and 80-fold increase in Cmax and AUC at the dose of 24 mg/kg) in rats[1].
storage
Desiccate at RT
4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride Suppliers
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