Anagliptin

Product Name: Anagliptin
CAS No.: 739366-20-2
Chemical Name: Anagliptin
Synonyms: Suiny;SK-0403;Anagliptin;SUINY;SK-0403;Anagliptin API;Anagliptin (SK-0403);(S)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylaMino)-2-Methylpropyl)-2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxaMide;(R)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylamino)-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide;N-[2-[[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide;N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CBNumber: CB52627327
Molecular Formula: C19H25N7O2
Formula Weight: 383.45
MOL File: 739366-20-2.mol

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Anagliptin Property

Melting point:: 115 - 119°C
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
form: Solid
pka: 12.40±0.46(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A637210
Product name: Anagliptin
Packaging: 1mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA31542
Product name: Anagliptin
Packaging: 2mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA31542
Product name: Anagliptin
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-4510
Product name: Anagliptin
Purity: ≥97.0%
Packaging: 10mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA31542
Product name: Anagliptin
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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Anagliptin Chemical Properties,Usage,Production

Description

Anagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that was approved in Japan in November 2012 for the treatment of patients with Type 2 diabetes mellitus (T2DM). Anagliptin (also known asSK-0403) is a treatment for diabetes based on inhibition of DPP-4, an enzyme that is responsible for degradation of glucagon-like peptide 1 (GLP-1), a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Following the introduction of the first DPP-4 inhibitor, sitagliptin, in 2006, several members of the gliptin class have been approved worldwide. Anagliptin was discovered from an effort to replace a metabolically labile isoindoline group from an earlier DPP-4 inhibitor series with a stable bioisostere. Anagliptin is a potent DPP-4 inhibitor, with an IC₅₀=3.8 nM and >10,000-fold selectivity over inhibition of DPP-8 and DPP-9.

Originator

Sanwa Kagaku Kenkyusho (Japan)

Uses

Anagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction. It also attenuates atherosclerosis in male apolipoprotein E-deficient mice.

Definition

ChEBI: Anagliptin is an amino acid amide.

brand name

Suiny

Clinical Use

Anagliptin, which is marketed as Beskoa or Suiny, is a dipeptidyl peptidase–IV (DPP-4) inhibitor which was approved in September 2012 and launched in November 2012 in Japan for the treatment of Type II diabetes. The drug was co-developed by three Japanese companies; Kowa, Sanwa Kagaku and JW pharmaceutical. Anagliptin, which is more selective against several recombinant human proteases by comparison to sitagliptin and vildagliptin, has more than 10,000-fold selectivity over the structurally homologous DPP-8 and DPP-9 enzymes.

Synthesis

The most likely process-scale synthesis has been published and is depicted in Scheme 3.24 Commercially available (S)-1-(2-chloroacetyl)-pyrrolidine-2-carbonitrile (12) was alkylated with t-butyl (2-amino-2-methyl-1-propyl)carbamate (13), giving rise to (S)-t-butyl (2-((2-(2-cyanopyrrolidin-1-yl)-2- oxoethyl)amino)-2-methylpropyl)carbamate (14). This Boc-protected system was subsequently treated with strong acid to give the ethylene diamine derivative 15 in 96% yield. Activation of 15 with CDI followed by coupling with commercially available 2-methylpyrazolo[1,5-a] pyrimidine-6-carboxylic acid (16) gave anagliptin (III) in 90% yield.

Anagliptin Preparation Products And Raw materials

Raw materials

Preparation Products

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Anagliptin Suppliers

China 98 France 1 India 6 United Kingdom 2 United States 12 Global 119

BOC Sciences

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MedChemexpress LLC

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AdooQ BioScience, LLC

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BOC Sciences

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Email: info@bocsci.com
Country: United States
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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Aladdin Scientific

Tel: +1-+1(833)-552-7181
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Country: United States
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TargetMol Chemicals Inc.

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Aceschem Inc.

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China.

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Cayman Chemical Company

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View Lastest Price from Anagliptin manufacturers

Henan Fengda Chemical Co., Ltd

Product: Anagliptin 739366-20-2
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: Anagliptin 739366-20-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Anagliptin 739366-20-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

739366-20-2, AnagliptinRelated Search:

CHLOROAC-PRO-OH 1-(2-CHLOROACETYL)PYRROLIDINE-2-CARBOXYLIC ACID Anagliptin hydrochloride Carbamic acid, (2-amino-1,1-dimethylethyl)-, 1,1-dimethylethyl ester (9CI) 2-Pyrrolidinecarbonitrile, 1-(chloroacetyl)- (9CI) Pidotimod Sitagliptin Alogliptin benzoate Anagliptin-d6

Anagliptin

N-[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]aMino]-2-Methylpropyl]-2-Methyl-6-pyrazolo[1,5-a]pyriMidinecarboxaMide

Anagliptin API

Suiny

(S)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylaMino)-2-Methylpropyl)-2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxaMide

N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

(R)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylamino)-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

N-[2-[[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

SK-0403

SUINY;SK-0403

Pyrazolo[1,5-a]pyrimidine-6-carboxamide, N-[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methyl-

Anagliptin (SK-0403)

Anagliptin-d7Q: What is Anagliptin-d7 Q: What is the CAS Number of Anagliptin-d7 Q: What is the storage condition of Anagliptin-d7 Q: What are the applications of Anagliptin-d7

AnagliptinQ: What is Anagliptin Q: What is the CAS Number of Anagliptin Q: What is the storage condition of Anagliptin Q: What are the applications of Anagliptin

739366-20-2