ChemicalBook > CAS DataBase List > BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-

BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-

Product Name
BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-
CAS No.
887936-68-7
Chemical Name
BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-
Synonyms
APD791;Temanogrel;Temanogrel, 10 mM in DMSO;3-methoxy-N-[3-(2-methylpyrazol-3-yl)-4-(2-morpholin-4-ylethoxy)phenyl]benzamide;3-Methoxy-N-[3-(1-methyl-1H-pyrazol-5-yl)-4-[2-(4-morpholinyl)ethoxy]phenyl]benzamide;BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-;inhibit,Temanogrel,Serotonin Receptor,5-HT Receptor,APD 791,APD-791,Inhibitor,5-hydroxytryptamine Receptor
CBNumber
CB52627392
Molecular Formula
C24H28N4O4
Formula Weight
436.5
MOL File
887936-68-7.mol
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BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Property

Boiling point:
556.4±50.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 125 mg/mL (286.37 mM)
form 
Solid
pka
12.88±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0002653
Product name
Temanogrel
Purity
98.94%
Packaging
1mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0002653
Product name
Temanogrel
Purity
98.94%
Packaging
5mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0002653
Product name
Temanogrel
Purity
98.94%
Packaging
10mg
Price
$750
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0292929
Product name
3-METHOXY-N-[3-(1-METHYL-1H-PYRAZOL-5-YL)-4-[2-(4-MORPHOLINYL)ETHOXY]PHENYL]BENZAMIDE
Purity
95.00%
Packaging
1G
Price
$1131.9
Updated
2021/12/16
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BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Chemical Properties,Usage,Production

Uses

Temanogrel, is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM. Temanogrel also inhibits inositol phosphate accumulation with an IC50 of 5.2 nM. Temanogrel exhibits potent inhibition of serotonin mediated amplification of ADP-stimulated human and dog platelet aggregation (IC50=8.7 and 23.1 nM, respectively

Definition

ChEBI: Temanogrel is a member of benzamides.

in vivo

There are no differences in heart rate or mean arterial pressure between saline-treated and Temanogrel-treated groups at any time during the experiment (that is, for mean arterial pressure, P=0.508 between groups, and P=0.540 for group-time interaction). In dogs assigned to receive Temanogrel, plasma Temanogrel levels show a rapid and sustained increase, averaging 25.5±4.1, 28.7±4.6 and 31.2±4.5 ng/mL, respectively, at 10 min, 1.25 h and 2.25 h after the start of treatment[3].

IC 50

5-HT2A Receptor: 4.9 nM (Ki)

BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Suppliers

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887936-68-7, BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-Related Search:


  • BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-
  • Temanogrel
  • 3-Methoxy-N-[3-(1-methyl-1H-pyrazol-5-yl)-4-[2-(4-morpholinyl)ethoxy]phenyl]benzamide
  • APD791
  • inhibit,Temanogrel,Serotonin Receptor,5-HT Receptor,APD 791,APD-791,Inhibitor,5-hydroxytryptamine Receptor
  • Temanogrel, 10 mM in DMSO
  • 3-methoxy-N-[3-(2-methylpyrazol-3-yl)-4-(2-morpholin-4-ylethoxy)phenyl]benzamide
  • 887936-68-7