BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-
- Product Name
- BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-
- CAS No.
- 887936-68-7
- Chemical Name
- BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-
- Synonyms
- APD791;Temanogrel;Temanogrel, 10 mM in DMSO;3-methoxy-N-[3-(2-methylpyrazol-3-yl)-4-(2-morpholin-4-ylethoxy)phenyl]benzamide;3-Methoxy-N-[3-(1-methyl-1H-pyrazol-5-yl)-4-[2-(4-morpholinyl)ethoxy]phenyl]benzamide;BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]-;inhibit,Temanogrel,Serotonin Receptor,5-HT Receptor,APD 791,APD-791,Inhibitor,5-hydroxytryptamine Receptor
- CBNumber
- CB52627392
- Molecular Formula
- C24H28N4O4
- Formula Weight
- 436.5
- MOL File
- 887936-68-7.mol
BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Property
- Boiling point:
- 556.4±50.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (286.37 mM)
- form
- Solid
- pka
- 12.88±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0002653
- Product name
- Temanogrel
- Purity
- 98.94%
- Packaging
- 1mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0002653
- Product name
- Temanogrel
- Purity
- 98.94%
- Packaging
- 5mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CS-0002653
- Product name
- Temanogrel
- Purity
- 98.94%
- Packaging
- 10mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- CHM0292929
- Product name
- 3-METHOXY-N-[3-(1-METHYL-1H-PYRAZOL-5-YL)-4-[2-(4-MORPHOLINYL)ETHOXY]PHENYL]BENZAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1131.9
- Updated
- 2021/12/16
BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Chemical Properties,Usage,Production
Uses
Temanogrel, is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM. Temanogrel also inhibits inositol phosphate accumulation with an IC50 of 5.2 nM. Temanogrel exhibits potent inhibition of serotonin mediated amplification of ADP-stimulated human and dog platelet aggregation (IC50=8.7 and 23.1 nM, respectively
Definition
ChEBI: Temanogrel is a member of benzamides.
in vivo
There are no differences in heart rate or mean arterial pressure between saline-treated and Temanogrel-treated groups at any time during the experiment (that is, for mean arterial pressure, P=0.508 between groups, and P=0.540 for group-time interaction). In dogs assigned to receive Temanogrel, plasma Temanogrel levels show a rapid and sustained increase, averaging 25.5±4.1, 28.7±4.6 and 31.2±4.5 ng/mL, respectively, at 10 min, 1.25 h and 2.25 h after the start of treatment[3].
IC 50
5-HT2A Receptor: 4.9 nM (Ki)
BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
BenzaMide, 3-Methoxy-N-[3-(1-Methyl-1H-pyrazol-5-yl)-4-[2-(4-Morpholinyl)ethoxy]phenyl]- Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58