2-Acetylfuro-1,4-naphthoquinone
- Product Name
- 2-Acetylfuro-1,4-naphthoquinone
- CAS No.
- 83280-65-3
- Chemical Name
- 2-Acetylfuro-1,4-naphthoquinone
- Synonyms
- 139057;CS-945;BBI-606;Napabucasin;Napabucasin Impurity;Remimazolam besylate;Napabucasin (BBI608);Napabucasin, 10 mM in DMSO;Napabucasin (BBI608) ，S7977;2-Acetylfuro-1,4-phthoquinone
- CBNumber
- CB52667637
- Molecular Formula
- C14H8O4
- Formula Weight
- 240.21
- MOL File
- 83280-65-3.mol
2-Acetylfuro-1,4-naphthoquinone Property
- Melting point:
- 225-226℃ (dichloromethane )
- Boiling point:
- 444.4±45.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO (up to 20 mg/ml)
- form
- Brown solid
- color
- Yellow
- λmax
- 272nm(EtOH)(lit.)
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3
- InChIKey
- DPHUWDIXHNQOSY-UHFFFAOYSA-N
- SMILES
- O1C(C(C)=O)=CC2C(=O)C3=C(C(=O)C1=2)C=CC=C3
Safety
- HS Code
- 2932.99.7000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.33851
- Product name
- Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem
- Packaging
- 10mg
- Price
- $113
- Updated
- 2025/07/31
- Product number
- A3110
- Product name
- 2-Acetylnaphtho[2,3-b]furan-4,9-dione
- Purity
- >98.0%(GC)
- Packaging
- 25mg
- Price
- $165
- Updated
- 2025/07/31
- Product number
- A3110
- Product name
- 2-Acetylnaphtho[2,3-b]furan-4,9-dione
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $457
- Updated
- 2025/07/31
- Product number
- 22255
- Product name
- Napabucasin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 22255
- Product name
- Napabucasin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $116
- Updated
- 2024/03/01
2-Acetylfuro-1,4-naphthoquinone Chemical Properties,Usage,Production
Description
Napabucasin is an inhibitor of cancer cell stemness. It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.
Uses
Napabucasin is a cancer cell stemness inhibitor which attenuates the progression of prostate cancer.
in vivo
Napabucasin (40 mg/kg) or Docetaxel significantly reduces xenograft tumor growth and tumor volume (TV) compared with PBS (P<0.05). Notably, while no differences are observed between the Napabucasin and the docetaxel groups in PC-3 mouse xenograft models, the TV in Napabucasin group is even lower than docetaxel group in 22RV1 mouse xenograft models (P<0.05). Additionally, Napabucasin or docetaxel also significantly reduces tumor weight compared with PBS (P<0.05)[1].
IC 50
STAT3
storage
Store at -20°C
References
[1] YOUZHI LI. Suppression of cancer relapse and metastasis by inhibiting cancer stemness.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015: 1839-1844. DOI:10.1073/pnas.1424171112
[2] JOLEEN M HUBBARD Axel G. Napabucasin: An Update on the First-in-Class Cancer Stemness Inhibitor.[J]. Drugs, 2017, 77 10: 1091-1103. DOI:10.1007/s40265-017-0759-4
[3] YIMING ZHANG. Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin[J]. Cancer Medicine, 2016, 5 6: 1251-1258. DOI:10.1002/cam4.675
[4] LAUREN MACDONAGH . BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC[J]. Cancer letters, 2018, 428: Pages 117-126. DOI:10.1016/j.canlet.2018.04.008
2-Acetylfuro-1,4-naphthoquinone Preparation Products And Raw materials
Raw materials
Preparation Products
2-Acetylfuro-1,4-naphthoquinone Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 2-Acetylfuro-1,4-naphthoquinone manufacturers
- Product
- Napabucasin 83280-65-3
- Price
- US $2.00-6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-ton
- Release date
- 2025-07-28
- Product
- Napabucasin 83280-65-3
- Price
- US $1.20/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 10 tons min
- Release date
- 2022-10-09
- Product
- Napabucasin(BBI-608) 83280-65-3
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-09-16