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GSK 2801

Product Name
GSK 2801
CAS No.
1619994-68-1
Chemical Name
GSK 2801
Synonyms
CS-1607;GSK2801;GSK 280;GSK 2801;GSK-2801;GSK2801, >98%;GSK-2801; GSK 280;GSK2801 GSK-2801;GSK2801;GSK-2801;GSK 2801;1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone
CBNumber
CB52668513
Molecular Formula
C20H21NO4S
Formula Weight
371.45
MOL File
1619994-68-1.mol
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GSK 2801 Property

Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥2.82 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
color 
Light yellow to khaki
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14120
Product name
GSK2801
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14120
Product name
GSK2801
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Tocris
Product number
5635
Product name
GSK2801
Purity
≥98%(HPLC)
Packaging
10
Price
$160
Updated
2021/12/16
TRC
Product number
G797680
Product name
GSK2801
Packaging
25mg
Price
$335
Updated
2021/12/16
TRC
Product number
G797680
Product name
GSK2801
Packaging
1mg
Price
$55
Updated
2021/12/16
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GSK 2801 Chemical Properties,Usage,Production

Description

BAZ2A/B are bromodomain-containing proteins whose biological function is believed to function similarly to ACF1, the Drosophila BAZ2B ortholog. ACF complexes play roles in establishing regular nucleosome spacing during chromatin assembly and influencing different remodeling outcomes at target loci. BAZ2A and BAZ2B constitute the central scaffolding protein of the nucleolar remodeling complex (NoRC) that regulates the expression of noncoding RNAs. GSK2801 is a selective, cell-permeable inhibitor of the BAZ2 family of bromodomain-containing proteins (IC50s = 9-350 nM in a BAZ2B AlphaScreen). It binds to BAZ2A and BAZ2B with Kd values of 0.26 and 0.14 μM, respectively, and does not interact with the bromodomains of BRD4(BD1), CREBBP, TRIM24/TIF1α, PB1(BD5), PCAF, or ATAD2. See the Structural Genomics Consortium (SGC) website for more information.

Uses

GSK2801 is a selective cell-permeable inhibitor of the BAZ2 (bromodomain-containing protein) interfering with nucleosome spacing during chromatin assembly.

References

[1]. chen p, chaikuad a, bamborough p, et al. discovery and characterization of gsk2801, a selective chemical probe for the bromodomains baz2a and baz2b. journal of medicinal chemistry, 2015.

GSK 2801 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK 2801 Suppliers

China 68 India 1 United Kingdom 1 United States 14 Global 84
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from GSK 2801 manufacturers

Career Henan Chemical Co
Product
GSK 2801 1619994-68-1
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

1619994-68-1, GSK 2801Related Search:

GSK2814338 GSK-2256098 GSK-25 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK2636771 GSK2879552 GSK2795039 GSK 2330672 GSK2838232

  • GSK 2801
  • GSK2801
  • GSK-2801
  • 1-(7-(2-Methylsulfonyl-phenyl)-4-propoxy-1-aza-bicyclo[4.3.0]nona-2,4,6,8-tetraen-9-yl)-ethanone
  • 1-(1-(2-(methylsulfonyl)phenyl)-7-propoxyindolizin-3-yl)ethanone
  • 1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone
  • GSK2801 GSK-2801
  • 1-[1-(2-Methanesulfonyl-phenyl)-7-propoxy-indolizin-3-yl]-ethanone
  • GSK2801;GSK-2801;GSK 2801
  • CS-1607
  • GSK2801, >98%
  • GSK 280
  • GSK-2801; GSK 280
  • Ethanone, 1-[1-[2-(methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]-
  • inhibit,Inhibitor,GSK-2801,TNBC,BAZ2A,GSK2801,Epigenetic Reader Domain,Apoptosis,BAZ2B,cetyl-lysine,orally,GSK 2801
  • 1619994-68-1
  • Inhibitors