ChemicalBook > CAS DataBase List > Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate
Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate
- Product Name
- Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate
- CAS No.
- 1224944-51-7
- Chemical Name
- Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate
- Synonyms
- Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate;Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-chloro-, methyl ester
- CBNumber
- CB52679164
- Molecular Formula
- C8H6ClN3O2
- Formula Weight
- 211.61
- MOL File
- 1224944-51-7.mol
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Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate Property
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.44±0.40(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H6ClN3O2/c1-14-8(13)5-4-10-12-3-2-6(9)11-7(5)12/h2-4H,1H3
- InChIKey
- FDJUGKZMZUVEJD-UHFFFAOYSA-N
- SMILES
- C12=C(C(OC)=O)C=NN1C=CC(Cl)=N2
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N-Bromosuccinimide Price
TRC
- Product number
- M340530
- Product name
- Methyl5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0369540
- Product name
- METHYL-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.11
- Updated
- 2021/12/16
Ambeed
- Product number
- A232728
- Product name
- Methyl5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $31
- Updated
- 2021/12/16
Chemenu
- Product number
- CM131209
- Product name
- methyl5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $62
- Updated
- 2021/12/16
Ambeed
- Product number
- A232728
- Product name
- Methyl5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $126
- Updated
- 2021/12/16
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Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate Chemical Properties,Usage,Production
Synthesis
67-56-1
1224944-46-0
1224944-51-7
5-Oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid (151 mg, 0.84 mmol, 1.0 eq.) was mixed with phosphorus trichloride (20 mL) and N,N-diisopropylethylamine (440 μL, 2.5 mmol, 3.0 eq.) and heated at reflux for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and allowed to stand overnight, followed by concentration under reduced pressure. The concentrated residue was dissolved in methanol (20 mL), stirred for 30 minutes and concentrated again under vacuum. The residue was partitioned between ethyl acetate and water, the organic phase was separated, washed with brine, dried over anhydrous sodium sulfate, filtered through a silica gel pad and finally concentrated to give methyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate (160 mg, 90% yield). The product was analyzed by LCMS (ESI), m/z [M+H]+ = 212.2; 1H NMR (400 MHz, DMSO-d6) δ: 9.34 (d, 1H), 8.68 (s, 1H), 7.42 (d, 1H), 3.83 (s, 3H).
References
[1] Patent: US2012/22043, 2012, A1. Location in patent: Page/Page column 35
Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate manufacturers
Xiamen Yunfan Biotech Co.,Ltd.
- Product
- Methyl 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate 1224944-51-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100 Kg/Month
- Release date
- 2024-07-02