ChemicalBook > CAS DataBase List > (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone

(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone

Product Name
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
CAS No.
432020-20-7
Chemical Name
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
Synonyms
SMI481;NPPM6748481;NPPM 6748481;NPPM-6748-481;NPPM 6748-481;SID: 164348711;SMI-481 SMI 481;SMI481, 10 mM in DMSO;Inhibitor,SMI481,SMI-481,inhibit;1-(4-Chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)-piperazine
CBNumber
CB52715743
Molecular Formula
C17H15ClFN3O3
Formula Weight
363.7707032
MOL File
432020-20-7.mol
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(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Property

Boiling point:
543.3±50.0 °C(Predicted)
Density 
1.411±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear
pka
1.04±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1090
Product name
SMI481
Purity
≥98% (HPLC)
Packaging
5mg
Price
$102
Updated
2022/05/15
Sigma-Aldrich
Product number
SML1090
Product name
SMI481
Purity
≥98% (HPLC)
Packaging
25mg
Price
$410
Updated
2022/05/15
Cayman Chemical
Product number
17637
Product name
SMI-481
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17637
Product name
SMI-481
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17637
Product name
SMI-481
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
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(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Chemical Properties,Usage,Production

Uses

SMI-481 is a yeast phosphatidylinositol transfer proteins (PITP) Sec14 inhibitor.

Biological Activity

SMI481 is a selective small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer protein (PITP) Sec14, a key regulator of phosphoinositide signaling, regulating membrane trafficking through the trans-Golgi network and endosomal systems. SMI481 has an IC50 value of 211 ± 19 nM in vitro against S. cerevisiae Sec14 (WT) in a phosphatidylinositol (PtdIns) transfer assay measuring exchange of PtdIns and phosphatidylcholine between membranes and inhibited Sec14-dependent growth of WT yeast with an IC50 of 2.87 ± 0.55 μM. SMI481μs activity is believed to involve binding in the Sec14 hydrophobic cavity, a new target for studying phosphoinositide signaling with more selectivity than th at afforded by lipid kinase–directed strategies.

(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Suppliers

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432020-20-7, (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)MethanoneRelated Search:

6-aMino-9-benzyl-2-(2-Methoxyethoxy)-9H-purin-8-ol SMI-4a N-(4-BroMophenyl)-3,5-diMethyl-1-piperidinepropanaMide Hydrochloride 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol hydrochloride SM1-71 SM 7368 SMI-16a SM-276001

  • (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
  • 1-(4-Chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)-piperazine
  • SID: 164348711
  • SMI481
  • Methanone, (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]-
  • NPPM 6748481
  • NPPM 6748-481
  • NPPM6748481
  • NPPM-6748-481
  • SMI-481 SMI 481
  • Inhibitor,SMI481,SMI-481,inhibit
  • SMI481, 10 mM in DMSO
  • 432020-20-7