ChemicalBook > CAS DataBase List > BGT226

BGT226

Product Name
BGT226
CAS No.
915020-55-2
Chemical Name
BGT226
Synonyms
BGT-226 free base;BGT226, 10 mM in DMSO;inhibit,Mammalian target of Rapamycin,BGT226,PI3K,BGT 226,Autophagy,BGT-226,Inhibitor,mTOR,Phosphoinositide 3-kinase;8-(6-Methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-trifluoromethylphenyl]-1,3-dihydroimidazo[4,5-c]quinolin-2-one;8-(6-Methoxypyridin-3-yl)-3-methyl-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one;2H-Imidazo[4,5-c]quinolin-2-one, 1,3-dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-
CBNumber
CB52731024
Molecular Formula
C28H25F3N6O2
Formula Weight
534.53
MOL File
915020-55-2.mol
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BGT226 Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M226705
Product name
8-(6-Methoxypyridin-3-yl)-3-methyl-1-(4-piperazin-1-yl)-3-(trifluoromethyl)phenyl-1H-imidazol[4,5-c]quinolin-2(3H)-one
Packaging
2.5mg
Price
$260
Updated
2021/12/16
AK Scientific
Product number
SYN1178A
Product name
BGT-226freebase
Packaging
100mg
Price
$1615
Updated
2021/12/16
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BGT226 Chemical Properties,Usage,Production

Uses

8-(6-Methoxypyridin-3-yl)-3-methyl-1-(4-piperazin-1-yl)-3-(trifluoromethyl)phenyl-1H-imidazol[4,5-c]quinolin-2(3H)-one is an intermediate used in the screening of anti-prostate cancer drug targeting PI3K-AKT-mTOR pathway.

Definition

ChEBI: BGT226 free base is an imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 3-trifluoromethyl-4-(piperazin-1-yl)phenyl group and at position 8 by a 6-methoxypyridin-3-yl group. A dual PI3K/mTOR inhibitor. It has a role as an antineoplastic agent, a mTOR inhibitor and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is an imidazoquinoline, a N-arylpiperazine, a member of pyridines, an organofluorine compound and an aromatic ether. It is a conjugate base of a BGT226(1+).

in vivo

BGT226 (2.5 and 5 mg/kg; oral administration for 21 days in male athymic mice) causes 34.7% and 76.1% reduction of the tumor growth on day 21 compared with control[2].

Animal Model:Male athymic mice (strain BALB/cAnN.Cg-Foxn1nu/CrlNarl) with FaDu cell xenografted mouse model[2]
Dosage:2.5 and 5 mg/kg
Administration:Oral administration; 21 days
Result:Caused 34.7% and 76.1% reduction of the tumor growth.

IC 50

PI3Kα: 4 nM (IC50); PI3Kβ: 63 nM (IC50); PI3Kγ: 38 nM (IC50); mTOR; Autophagy

BGT226 Preparation Products And Raw materials

Raw materials

Preparation Products

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BGT226 Suppliers

China 23 India 1 United Kingdom 1 United States 4 Global 29
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
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China
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3506
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
ProdList
4757
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Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
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huahero21@sina.com
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China
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2390
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55
Pharmacodia (Beijing) Co.,Ltd
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+86-400-851-9921
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+86-10-82826195
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sales@pharmacodia.com
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China
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2317
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
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9803
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58
Amadis Chemical Company Limited
Tel
571-89925085
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0086-571-89925065
Email
sales@amadischem.com
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China
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131957
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Zhongshan Geometric Biological Technology Co., Ltd.
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Email
2953972351@qq.com
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China
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253
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58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
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China
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4587
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Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2995
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58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
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2881924765@qq.com
Country
China
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7941
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
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China
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62220
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58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
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6753
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TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
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24961
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Shanghai Tachizaki Biomedical Research Center
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18014399201
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sales@chemlab-tachizaki.com
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China
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2742
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https://hanhongsci.com/
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021-54306202 18917919676
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info@hanhongsci.com
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China
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29995
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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China
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9835
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
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025-58851090 17714375163
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2881759498@qq.com
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China
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13011
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Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026
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Sales@sangon.com
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China
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6710
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58
Nantong HI-FUTURE Biology Co., Ltd.
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+undefined18051384581
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sales@chemhifuture.com
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China
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3135
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58
Absin Bioscience Inc.
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chenjw@absin.cn
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CHINA
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6208
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Proteintech China
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--
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Email
Proteintech-CN@ptglab.com
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CHINA
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6290
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58
Debye Scientific Corporation
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--
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China
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6891
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915020-55-2, BGT226Related Search:


  • BGT-226 free base
  • 8-(6-Methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-trifluoromethylphenyl]-1,3-dihydroimidazo[4,5-c]quinolin-2-one
  • 2H-Imidazo[4,5-c]quinolin-2-one, 1,3-dihydro-8-(6-methoxy-3-pyridinyl)-3-methyl-1-[4-(1-piperazinyl)-3-(trifluoromethyl)phenyl]-
  • inhibit,Mammalian target of Rapamycin,BGT226,PI3K,BGT 226,Autophagy,BGT-226,Inhibitor,mTOR,Phosphoinositide 3-kinase
  • 8-(6-Methoxypyridin-3-yl)-3-methyl-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one
  • BGT226, 10 mM in DMSO
  • 915020-55-2
  • C28H25F3N6O2