INCB39110

Product Name: INCB39110
CAS No.: 1334302-63-4
Chemical Name: INCB39110
Synonyms: INCB39110;Itacitinib adipate;Itacitinib adipate (INCB 39110 adipate);2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate;3-azetidineacetonitrile, 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-pyrazol-1-yl]-,hexanedioic acid salt;2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile INCB39110
CBNumber: CB52731286
Molecular Formula: C32H33F4N9O5
Formula Weight: 699.67
MOL File: 1334302-63-4.mol

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INCB39110 Property

storage temp.: Store at -20°C
solubility: DMSO: ≥ 137.5 mg/mL (196.52 mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0040822
Product name: Itacitinibadipate
Purity: 99.37%
Packaging: 1mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0040822
Product name: Itacitinibadipate
Purity: 99.37%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0040822
Product name: Itacitinibadipate
Purity: 99.37%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0040822
Product name: Itacitinibadipate
Purity: 99.37%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0040822
Product name: Itacitinibadipate
Purity: 99.37%
Packaging: 100mg
Price: $1300
Updated: 2021/12/16

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INCB39110 Chemical Properties,Usage,Production

Uses

Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.

IC 50

JAK1

References

[1] Griesshammer M, et al. The BCR-ABL1-negative myeloproliferative neoplasms: a review of JAK inhibitors in the therapeutic armamentarium. Expert Opin Pharmacother. 2017 Dec;18(18):1929-1938. DOI:10.1080/14656566.2017.1404574

INCB39110 Preparation Products And Raw materials

Raw materials

Preparation Products

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INCB39110 Suppliers

China 25 United States 5 Global 30

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1334302-63-4, INCB39110Related Search:

INCB39110

2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile INCB39110

Itacitinib adipate

3-azetidineacetonitrile, 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-pyrazol-1-yl]-,hexanedioic acid salt

Itacitinib adipate (INCB 39110 adipate)

2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate

1334302-63-4