2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

Product Name: 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS No.: 1258292-64-6
Chemical Name: 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
Synonyms: GDC-046;GDC-046;GDC 046;2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide;Benzamide, 2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-;2,6 Dichloro N (2 (cyclopropanecarboxamido)pyridin 4 yl)benzamide,JAK1,IBD,JAK,2,6DichloroN(2(cyclopropanecarboxamido)pyridin4yl)benzamide,inflammatory,TYK2,bowel,Janus kinase,Inhibitor,inhibit,IL-12,diseases,JAK3,JAK2,IL-23
CBNumber: CB52738245
Molecular Formula: C16H13Cl2N3O2
Formula Weight: 350.2
MOL File: 1258292-64-6.mol

More

Less

2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Property

storage temp.: 4°C, protect from light
solubility: DMSO : 62.5 mg/mL (178.47 mM; Need ultrasonic)
form: A solid
color: Off-white to yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 36601
Product name: GDC-046
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2026/04/30

Cayman Chemical

Product number: 36601
Product name: GDC-046
Purity: ≥98%
Packaging: 5mg
Price: $163
Updated: 2026/04/30

Cayman Chemical

Product number: 36601
Product name: GDC-046
Purity: ≥98%
Packaging: 10mg
Price: $304
Updated: 2026/04/30

Cayman Chemical

Product number: 36601
Product name: GDC-046
Purity: ≥98%
Packaging: 25mg
Price: $433
Updated: 2026/04/30

Adipogen Life Sciences

Product number: SYN-1198-M001
Product name: GDC-046
Purity: ≥95%
Packaging: 1mg
Price: $97
Updated: 2021/12/16

More

Less

2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Chemical Properties,Usage,Production

Uses

GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively[1].

in vivo

In mice, GDC-046 exhibits relatively high clearance (65 mL/min/kg) when dosed intravenously (i.v. 1 mg/kg) and exhibits modest oral exposure (AUC=2.6 μM·h at p.o. 5 mg/kg)^[1].

IC 50

Tyk2: 4.8 nM (Ki); JAK1: 0.7 nM (Ki); JAK2: 0.7 nM (Ki); JAK3: 0.4 nM (Ki)

References

[1] Jun Liang, et al. Lead Optimization of a 4-aminopyridine Benzamide Scaffold to Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J Med Chem. 2013 Jun 13;56(11):4521-36. DOI:10.1021/jm400266t

2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Suppliers

China 42 United Kingdom 1 United States 3 Global 46

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9955
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29661
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

1258292-64-6, 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamideRelated Search:

giredestrant (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide GDC0575 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide GDC-0077 (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one XL518 DONEPEZIL HYDROCHLORIDE

2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

GDC-046

GDC-046;GDC 046

Benzamide, 2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-

2,6 Dichloro N (2 (cyclopropanecarboxamido)pyridin 4 yl)benzamide,JAK1,IBD,JAK,2,6DichloroN(2(cyclopropanecarboxamido)pyridin4yl)benzamide,inflammatory,TYK2,bowel,Janus kinase,Inhibitor,inhibit,IL-12,diseases,JAK3,JAK2,IL-23

1258292-64-6