2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide

Product Name: 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide
CAS No.: 1449236-96-7
Chemical Name: 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide
Synonyms: NMS-859, 10 mM in DMSO;2-Chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]phenyl}acetamide;2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide;Acetamide, 2-chloro-N-[3-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenyl]-
CBNumber: CB52738487
Molecular Formula: C15H12ClN3O3S
Formula Weight: 349.79
MOL File: 1449236-96-7.mol

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2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 42 mg/mL (120.07 mM)
form: Solid
pka: 12.40±0.70(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3929
Product name: NMS-859
Purity: 97.65%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-3929
Product name: NMS-859
Purity: 97.65%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-3929
Product name: NMS-859
Purity: 97.65%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-3929
Product name: NMS-859
Purity: 97.65%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

Crysdot

Product number: CD31003439
Product name: NMS-859
Purity: 98+%
Packaging: 5mg
Price: $243
Updated: 2021/12/16

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2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Chemical Properties,Usage,Production

Uses

NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

References

[1] Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56. DOI:10.1038/nchembio.1313

2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide Suppliers

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1449236-96-7, 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamideRelated Search:

2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide

2-Chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]phenyl}acetamide

Acetamide, 2-chloro-N-[3-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenyl]-

NMS-859, 10 mM in DMSO

1449236-96-7