2-Amino-5-chloro-4-fluoro-benzoic acid
- Product Name
- 2-Amino-5-chloro-4-fluoro-benzoic acid
- CAS No.
- 351367-77-6
- Chemical Name
- 2-Amino-5-chloro-4-fluoro-benzoic acid
- Synonyms
- 5-Chloro-4-fluoroanthranilic Acid;2-Amino-5-chloro-4-fluoro-benzoic acid;BENZOIC ACID, 2-AMINO-5-CHLORO-4-FLUORO-
- CBNumber
- CB52746158
- Molecular Formula
- C7H5ClFNO2
- Formula Weight
- 189.57
- MOL File
- 351367-77-6.mol
2-Amino-5-chloro-4-fluoro-benzoic acid Property
- Melting point:
- >250 °C (dec.)
- Boiling point:
- 350.3±42.0 °C(Predicted)
- Density
- 1.574±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly)
- form
- Solid
- pka
- 4.51±0.10(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A605598
- Product name
- 2-Amino-5-chloro-4-fluoro-benzoicAcid
- Packaging
- 250mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- 1518AJ
- Product name
- 2-Amino-5-chloro-4-fluoro-benzoicacid
- Packaging
- 1g
- Price
- $298
- Updated
- 2021/12/16
- Product number
- 4657-7-28
- Product name
- 2-Amino-5-chloro-4-fluorobenzoic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $313
- Updated
- 2021/12/16
- Product number
- HCH0357514
- Product name
- 2-AMINO-5-CHLORO-4-FLUOROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.52
- Updated
- 2021/12/16
- Product number
- HCH0357514
- Product name
- 2-AMINO-5-CHLORO-4-FLUOROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $800
- Updated
- 2021/12/16
2-Amino-5-chloro-4-fluoro-benzoic acid Chemical Properties,Usage,Production
Synthesis
446-32-2
351367-77-6
Step-1: 2-Amino-4-fluorobenzoic acid (50 g, 322.6 mmol) was dissolved in 700 mL of N,N-dimethylformamide (DMF) followed by addition of N-chlorosuccinimide (41 g, 305.5 mmol) in batches. The reaction mixture was heated at 50 °C with stirring for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water to precipitate a solid. The solid was collected by filtration, dissolved in ethyl acetate (EtOAc) and washed with saturated sodium chloride solution (300 mL). The aqueous layer was back-extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the product 2-amino-5-chloro-4-fluorobenzoic acid (42 g, 69% yield) as a brown solid.
References
[1] Patent: WO2016/171755, 2016, A1. Location in patent: Paragraph 0101
[2] Patent: US2016/311818, 2016, A1. Location in patent: Paragraph 0465; 0466
[3] Patent: US2010/120741, 2010, A1. Location in patent: Page/Page column 122
[4] Patent: WO2011/112731, 2011, A2. Location in patent: Page/Page column 251
2-Amino-5-chloro-4-fluoro-benzoic acid Preparation Products And Raw materials
Raw materials
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