SR1824

Product Name: SR1824
CAS No.: 1338259-06-5
Chemical Name: SR1824
Synonyms: SR1824;HBMXDCXJXYASGW-NRFANRHFSA-N;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[5-[[[(1S)-1-(4-bromophenyl)ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]-
CBNumber: CB53039567
Molecular Formula: C33H29BrN2O3
Formula Weight: 581.5
MOL File: 1338259-06-5.mol

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SR1824 Property

Boiling point:: 809.7±65.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 3.87±0.36(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11087
Product name: SR 1824
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 11087
Product name: SR 1824
Purity: ≥98%
Packaging: 5mg
Price: $254
Updated: 2024/03/01

Cayman Chemical

Product number: 11087
Product name: SR 1824
Purity: ≥98%
Packaging: 10mg
Price: $466
Updated: 2024/03/01

Cayman Chemical

Product number: 11087
Product name: SR 1824
Purity: ≥98%
Packaging: 25mg
Price: $997
Updated: 2024/03/01

TRC

Product number: S684000
Product name: SR1824
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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SR1824 Chemical Properties,Usage,Production

Description

Peroxisome proliferator-activated receptor γ (PPARγ) is activated by the anti-diabetes drugs known as thiazolidinediones, including rosiglitazone and pioglitazone . Phosphorylation of PPARγ by cyclin-dependent kinase 5 (Cdk5) causes dysregulation of genes whose expression is altered in obesity, including adiponectin. SR 1824 is a non-agonist PPARγ ligand (K_i = 10 nM) which blocks Cdk5-mediated phosphorylation. It does not inhibit activation of PPARγ by rosiglitazone .

Uses

SR 1824 is a non-agonist Peroxisome proliferator-activated receptor γ (PPARγ) ligand.

in vitro

in a previous study, sr1824 was characterized for its ability to block cdk5-dependent phosphorylation of pparγ. the results demonstrated that sr1824 could potently block cdk5-dependent phosphorylation of pparc in cells while displaying little to no classical agonism. in the docking study, the hdx analyses showed that sr1824 and its analog of sr1664 werer able to increase the conformational mobility of the c-terminal end of h11, a helix that abuts h12; in contrast, the full and partial agonists could stabilize the same region of h11. morover, as expected sr1664 and sr1824 did not interact with h12 in any detectable way, but unexpectedly both ligands cause an increase in the conformational mobility of h11, which was part of the af2 surface and directly abuts h12 [1].

References

[1] choi, j. h.,banks, a.s.,kamenecka, t.m., et al. antidiabetic actions of a non-agonist pparγ ligand blocking cdk5-mediated phosphorylation. nature 477(7365), 477-481 (2011).

SR1824 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR1824 Suppliers

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1338259-06-5, SR1824Related Search:

SR1824

HBMXDCXJXYASGW-NRFANRHFSA-N

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[5-[[[(1S)-1-(4-bromophenyl)ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]-

1338259-06-5

C33H29BrN2O3