ChemicalBook > CAS DataBase List > Ethyl sarcosinate hydrochloride

Ethyl sarcosinate hydrochloride

Product Name
Ethyl sarcosinate hydrochloride
CAS No.
52605-49-9
Chemical Name
Ethyl sarcosinate hydrochloride
Synonyms
SARCOSINE ETHYL ESTER HYDROCHLORIDE;H-SAR-OET·HCL;Ethyl sarcosinate HCL;ethyl methylglycinate hydrochloride;ethyl N-methylaminoacetate hydrochloride;ethyl 2-(methylamino)acetate hydrochloride;SAR-OET HCL;H-SAR-OE HCL;L-Sar-OEt·HCl;H-SAR-OET HCL
CBNumber
CB5305289
Molecular Formula
C5H12ClNO2
Formula Weight
153.61
MOL File
52605-49-9.mol
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Ethyl sarcosinate hydrochloride Property

Melting point:
~125 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
H2O: 0.1 g/mL, clear
form 
Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble in water 0.1 g/mL.
Sensitive 
Hygroscopic
BRN 
3911182
InChI
InChI=1S/C5H11NO2.ClH/c1-3-8-5(7)4-6-2;/h6H,3-4H2,1-2H3;1H
InChIKey
NIDZUMSLERGAON-UHFFFAOYSA-N
SMILES
C(=O)(OCC)CNC.Cl
CAS DataBase Reference
52605-49-9(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
HS Code 
29299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
255084
Product name
Sarcosine ethyl ester hydrochloride
Purity
99%
Packaging
10g
Price
$79.7
Updated
2025/07/31
Sigma-Aldrich
Product number
255084
Product name
Sarcosine ethyl ester hydrochloride
Purity
99%
Packaging
50g
Price
$267
Updated
2023/06/20
TCI Chemical
Product number
S0841
Product name
Sarcosine Ethyl Ester Hydrochloride
Purity
>98.0%(N)(T)
Packaging
5g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
S0841
Product name
Sarcosine Ethyl Ester Hydrochloride
Purity
>98.0%(N)(T)
Packaging
25g
Price
$107
Updated
2025/07/31
TRC
Product number
S140510
Product name
Sarcosine ethyl ester hydrochloride
Packaging
50g
Price
$175
Updated
2021/12/16
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Ethyl sarcosinate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline solid

Uses

Sarcosine ethyl ester hydrochloride is a metabolite of Sarcosine (S140500), which as been found in starfish and sea urchins. It is used as intermediate in the synthesis of antienzyme agents for toothpaste. Found to be a marker for prostate cancer bioagression.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

107-97-1

52605-49-9

Thiophenecarbonyl chloride (65 mL, 900 mmol) was added dropwise to a solution of sarcosine (20.0 g, 224 mmol) in ethanol (250 mL) cooled in an ice-water bath under stirring conditions, and the reaction temperature was maintained at about -10°C. After the dropwise addition was completed, the reaction mixture was gently heated at 55°C overnight until the solution became clear. Upon completion of the reaction, the solvent and residual thionyl chloride were removed by distillation under reduced pressure. The resulting solid residue was washed with ether (3 x 50 mL) and subsequently dried well under vacuum to afford ethyl sarcosinate hydrochloride (33.5 g, 218 mmol) in white powder form in 97% yield. The product could be used in subsequent steps without further purification. The product was characterized as follows: melting point 126°C (literature value 125-127°C); IR (ATR) ν cm?1 2970-2440, 1742, 1229; 1H NMR (CDCl?, 400 MHz) δ 9.64 (br.s, 2H, NH?), 4.24 (q, 2H, 3J = 7.1 Hz, CH?CH?), 3.84 (t, 2H, 3J = 7.1 Hz, CH?CH?), 4.24 (q, 2H, 3J = 7.1 Hz, CH? 3.84 (t, 2H, 3J = 5.7 Hz, NH?CH?), 2.80 (t, 3H, 3J = 5.2 Hz, NH?CH?), 1.26 (t, 3H, 3J = 7.1 Hz, CH?CH?); 13C NMR (CDCl?, 101 MHz) δ 166.18 (CO?), 62.62 (CH?CH?), 48.94 (NH?CH?), 33.34 (NH?CH?), 14.03 (CH?CH?).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 51 - 67
[2] Patent: US4432971, 1984, A
[3] Patent: US4432972, 1984, A

Ethyl sarcosinate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl sarcosinate hydrochloride Suppliers

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View Lastest Price from Ethyl sarcosinate hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl sarcosinate hydrochloride 52605-49-9
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-04
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-Sar-OEt.HCl 52605-49-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-04-08
Shaanxi Dideu New Materials Co. Ltd
Product
Ethyl sarcosinate hydrochloride 52605-49-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-10

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