6-Chloropyridine-3-sulfonamide
- Product Name
- 6-Chloropyridine-3-sulfonamide
- CAS No.
- 40741-46-6
- Chemical Name
- 6-Chloropyridine-3-sulfonamide
- Synonyms
- 6-Chloro-3-pyridinesulfonaMide;6-CHLOROPYRIDINE-3-SULFONAMIDE;3-Pyridinesulfonamide, 6-chloro-;6-Chloro-pyridine-3-sulfonic acid aMide;3-Pyridinesulfonamide,6-chloro-(7CI,9CI);6-Chloropyridine-3-sulfonamide ISO 9001：2015 REACH
- CBNumber
- CB5313985
- Molecular Formula
- C5H5ClN2O2S
- Formula Weight
- 192.62
- MOL File
- 40741-46-6.mol
6-Chloropyridine-3-sulfonamide Property
- Melting point:
- 158-159 °C(Solv: water (7732-18-5))
- Boiling point:
- 383.2±52.0 °C(Predicted)
- Density
- 1.558±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.24±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- C380355
- Product name
- 6-Chloro-3-pyridinesulfonamide
- Packaging
- 1g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- FC151483
- Product name
- 6-Chloropyridine-3-sulfonamide
- Packaging
- 100mg
- Price
- $62
- Updated
- 2021/12/16
- Product number
- Y9036
- Product name
- 6-Chloro-pyridine-3-sulfonicacidamide
- Packaging
- 100mg
- Price
- $103
- Updated
- 2021/12/16
- Product number
- FC151483
- Product name
- 6-Chloropyridine-3-sulfonamide
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FC151483
- Product name
- 6-Chloropyridine-3-sulfonamide
- Packaging
- 500mg
- Price
- $215
- Updated
- 2021/12/16
6-Chloropyridine-3-sulfonamide Chemical Properties,Usage,Production
Uses
6-Chloro-3-pyridinesulfonamide, is a heterocylic building block used for chemical synthesis. It can also be used for the synthesis of diuretics and carbonic anhydrase inhibitors.
Synthesis
6684-39-5
40741-46-6
The general procedure for the synthesis of 6-chloro-3-sulfapyridine from 2-chloropyridine-5-sulfonyl chloride was as follows: 6-chloropyridine-3-sulfonyl chloride (5.0 g, 0.024 mol) was dissolved in a 0.5 M ammonia dioxane solution (125 mL) at -50 °C. The reaction mixture was slowly warmed to room temperature and stirred continuously for 1 hour. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filter cake was washed twice with dioxane. The filtrate was concentrated in vacuum to afford 6-chloropyridine-3-sulfonic acid amide as an off-white solid in a yield of 4.55 g (98% yield). The product was analyzed by liquid chromatography (LC) under the detection condition of UV215 nm; retention time (Rt) 1.05 min and 100% purity. Mass spectrometry (m/z) analytical result (ES+): 193/195. NMR hydrogen spectroscopy (400 MHz; d6-DMSO) data: δ 8.79 (1H, d), 8.21 (1H, dd), 7.75 (1H, d), 7.70 (2H, br s).
References
[1] Patent: WO2008/49605, 2008, A1. Location in patent: Page/Page column 15-16
[2] Patent: WO2008/138594, 2008, A1. Location in patent: Page/Page column 16
[3] Patent: WO2008/21389, 2008, A2. Location in patent: Page/Page column 253
[4] Patent: WO2007/44729, 2007, A2. Location in patent: Page/Page column 186
[5] Patent: WO2008/127594, 2008, A2. Location in patent: Page/Page column 376
6-Chloropyridine-3-sulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloropyridine-3-sulfonamide manufacturers
- Product
- 6-Chloropyridine-3-sulfonamide 40741-46-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-28
- Product
- 6-Chloropyridine-3-sulfonamide 40741-46-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11