ChemicalBook > CAS DataBase List > Duvoglustat Hydrochloride

Duvoglustat Hydrochloride

Product Name: Duvoglustat Hydrochloride
CAS No.: 308362-25-6
Chemical Name: Duvoglustat Hydrochloride
Synonyms: SMT19969;Ridinilazole, 10 mM in DMSO;5,5'-Bi-1H-benzimidazole, 2,2'-di-4-pyridinyl-;2,2'-Di(pyridin-4-yl)-1H,1'H-5,5'-bibenzo[d]imidazole;2,2'-di(pyridin-4-yl)-3H,3'H-5,5'-bibenzo[d]imidazole;SMT 19969,inhibit,SMT-19969,Bacterial,Ridinilazole,Inhibitor
CBNumber: CB53159890
Molecular Formula: C24H16N6
Formula Weight: 388.42
MOL File: 308362-25-6.mol

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Duvoglustat Hydrochloride Property

Boiling point:: 774.9±70.0 °C(Predicted)
Density: 1.372±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 60 mg/mL (154.47 mM)
pka: 9.84±0.10(Predicted)
form: Solid
color: Light yellow to yellow
InChI: InChI=1S/C24H16N6/c1-3-19-21(29-23(27-19)15-5-9-25-10-6-15)13-17(1)18-2-4-20-22(14-18)30-24(28-20)16-7-11-26-12-8-16/h1-14H,(H,27,29)(H,28,30)
InChIKey: UHQFBTAJFNVZIV-UHFFFAOYSA-N
SMILES: C1(C2C=CN=CC=2)NC2=CC=C(C3=CC=C4NC(C5C=CN=CC=5)=NC4=C3)C=C2N=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6591
Product name: Ridinilazole
Purity: 99.51%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6591
Product name: Ridinilazole
Purity: 99.51%
Packaging: 5mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-6591
Product name: Ridinilazole
Purity: 99.51%
Packaging: 10mg
Price: $408
Updated: 2021/12/16

ChemScene

Product number: CS-6591
Product name: Ridinilazole
Purity: 99.51%
Packaging: 20mg
Price: $720
Updated: 2021/12/16

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Duvoglustat Hydrochloride Chemical Properties,Usage,Production

Uses

Ridinilazole is a novel antibacterial with MICs range of 0.06-0.25?μg/mL (MIC90=8?μg/mL) against C.?difficile.

in vivo

In a hamster model of CDI with a once-daily dosing regimen, Ridinilazole displays greater efficacy than Vancomycin both against non-epidemic and epidemic strains of C.?difficile. Similar to the twice-daily dosing study, plasma levels of Ridinilazole are below the level of detection, whereas caecal Ridinilazole concentrations are well above the MIC, thus demonstrating the non-absorbable nature of Ridinilazole and minimal systemic exposure^[1].

References

[1] Vickers RJ, et al. Ridinilazole: a novel therapy for Clostridium difficile infection. Int J Antimicrob Agents. 2016 Aug;48(2):137-43. DOI:10.1016/j.ijantimicag.2016.04.026

Duvoglustat Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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308362-25-6, Duvoglustat HydrochlorideRelated Search:

2,2'-di(pyridin-4-yl)-3H,3'H-5,5'-bibenzo[d]imidazole

SMT19969

5,5'-Bi-1H-benzimidazole, 2,2'-di-4-pyridinyl-

2,2'-Di(pyridin-4-yl)-1H,1'H-5,5'-bibenzo[d]imidazole

SMT 19969,inhibit,SMT-19969,Bacterial,Ridinilazole,Inhibitor

Ridinilazole, 10 mM in DMSO

308362-25-6