ACT-462206

Product Name: ACT-462206
CAS No.: 1361321-96-1
Chemical Name: ACT-462206
Synonyms: ACT-462206;ACT 462206,ACT462206;ACT-462206 >=98% (HPLC);ACT-462206, 10 mM in DMSO;(2S)-N-(3,5-DIMETHYLPHENYL)-1-(4-METHOXYPHENYL)SULFONYLPYRROLIDINE-2-CARBOXAMIDE;(2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide;2-Pyrrolidinecarboxamide, N-(3,5-dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-, (2S)-
CBNumber: CB53167703
Molecular Formula: C20H24N2O4S
Formula Weight: 388.48
MOL File: 1361321-96-1.mol

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ACT-462206 Property

Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 14.27±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1393
Product name: ACT-462206
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $86.92
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1393
Product name: ACT-462206
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $272
Updated: 2025/07/31

Tocris

Product number: 5319
Product name: ACT462206
Purity: ≥99%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

Tocris

Product number: 5319
Product name: ACT462206
Purity: ≥99%(HPLC)
Packaging: 50
Price: $815
Updated: 2021/12/16

TRC

Product number: A305313
Product name: ACT462206
Packaging: 2.5mg
Price: $220
Updated: 2021/12/16

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ACT-462206 Chemical Properties,Usage,Production

Uses

ACT-462206 is a potent and selective dual orexin receptor antagonist (DORA) that inhibits the stimulating effects of the orexin peptides at both the orexin 1 and 2 receptors. It decreases wakefulness and increases non-rapid eye movement (non-REM) and REM sleep while maintaining natural sleep architectures in some animal models while showing anxiolytic-like properties without affecting cognition and motor function in others.

Biological Activity

ACT-462206 is a orally active, brain penetrant, potent and selective dual orexin1/2 receptor antagonist (DORA). ACT-462206 decreases wakefulness, decreases sleep latency, and increases sleep efficacy in rats and dogs.', 'ACT-462206 is a proline sulphonamide with the potential to tre at insomnia. On absorption, its displays asthenia, blurred vision, and fatigue as adverse events.

in vivo

ACT-462206 (compound 24) (100 mg/kg; p.o.; sampling at 3 h) can go cross blood brain barrier, with concentrations are 2267 ng/mL and 1219 ng/g in plasma and brain, respectively in male Wistar rats^[1].
ACT-462206 (10-300 mg/kg; p.o.; single dose) shows sleep-promoting effects in male Wistar rats and in male Beagle dogs, with decreasing wakefulness and increasing non-rapid eye movement (non-REM) and REM sleep^[1].
ACT-462206 (100, 300 mg/kg; p.o.; single dose) exerts anxiolytic-like effects, decreases the fear-potentiated startle reflexes in response to a sudden loud noise in rats, reduces the socialstress-induced increases of locomotion, body temperature, and heart rate^[1].
Pharmacokinetics in different species^[1]

	Route	Dose (mg/kg)	AUC (ng h/mL)	CL (mL/min/kg)	V_ss (L/kg)	t_1/2 (h)	c_max (ng/mL)	t_max (h)	F_1/2 (%)
rat	i.v.	1	586	29	1.8	1.9	/	/	/
	p.o.	10	2310	/	/	/	1600	0.5	39
dog	i.v.	1	1490	11	1.4	1.7	/	/	/
	p.o.	3	2750	/	/	/	426	0.5	52

Animal Model:	Male Wistar rats^[1]
Dosage:	0, 10, 30, 100, 300 mg/kg
Administration:	Oral gavage; single dose
Result:	Decreased the latency to the first persistent episode of non-REM sleep (60 s) and the first persistent episode of REM sleep (30 s). Dose-dependently decreased total wake time and behavioral home cage activity (one-way ANOVA; p <0.001), while increasing REM and non-REM sleep times.

IC 50

OX2; OX1

storage

Store at +4°C

ACT-462206 Preparation Products And Raw materials

Raw materials

Preparation Products

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ACT-462206 Suppliers

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1361321-96-1, ACT-462206Related Search:

ACT-462206

(2S)-N-(3,5-DIMETHYLPHENYL)-1-(4-METHOXYPHENYL)SULFONYLPYRROLIDINE-2-CARBOXAMIDE

(2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide

ACT-462206 >=98% (HPLC)

ACT 462206,ACT462206

2-Pyrrolidinecarboxamide, N-(3,5-dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-, (2S)-

ACT-462206, 10 mM in DMSO

1361321-96-1