DDR1-IN-2
Uses- Product Name
- DDR1-IN-2
- CAS No.
- 1429617-90-2
- Chemical Name
- DDR1-IN-2
- Synonyms
- 7rh;DDR1-IN-2;7rh??(DDR1-IN-2);DDR1 Inhibitor 7rh;DDR1 Inhibitor 7rh >=98% (HPLC);DDR1 IN 2,Discoidin Domain Receptor,Inhibitor,7rh,inhibit,DDR-1-IN-2,DDR1IN2;4-Ethyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide;4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE;Benzamide, 4-ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)-
- CBNumber
- CB53367620
- Molecular Formula
- C30H29F3N6O
- Formula Weight
- 546.59
- MOL File
- 1429617-90-2.mol
DDR1-IN-2 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 62.5 mg/mL (114.35 mM)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1832
- Product name
- DDR1 Inhibitor 7rh
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- SML1832
- Product name
- DDR1 Inhibitor 7rh
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $217.2
- Updated
- 2024/03/01
- Product number
- CS-0035397
- Product name
- DDR1-IN-2
- Purity
- 98.62%
- Packaging
- 25mg
- Price
- $740
- Updated
- 2021/12/16
- Product number
- AS117230
- Product name
- DDR1-IN-2
- Purity
- 97+%
- Packaging
- 5mg
- Price
- $163
- Updated
- 2021/12/16
- Product number
- CS-0035397
- Product name
- DDR1-IN-2
- Purity
- 98.62%
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
DDR1-IN-2 Chemical Properties,Usage,Production
Uses
7rh is a useful research chemical compound.
Uses
7rh is a discoidin domain receptor 1 (DDR1) inhibitor useful in the study of similar derivatives as potential anticancer and anti-??inflammatory drugs.
General Description
DDR1 Inhibitor 7rh is a small potent kinase inhibitor of discoidin domain receptor-1 (DDR1). It inhibits the tumorigenicity of nasopharyngeal carcinoma (NPC) cells. DDR1 Inhibitor 7rh prevents the proliferation, invasion and adhesion of cancer cells.
Biochem/physiol Actions
DDR1 Inhibitor 7rh is an orally available, potent, ATP-competitive DDR1-selective inhibitor with in vitro and in vivo anti-cancer efficacy. Compound 7rh is a potent, high affinity (Kd =0.6 nM), ATP-competitive inhibitor against discoidin domain-containing receptor 1 (DDR1; IC50 = 6.8 nM, [ATP] = 100 nM) with significantly reduced potency toward 455 other kinases, including DDR2, Bcr-abl, and c-Kit (IC50 = 101.4 nM, 355 nM and >10 μM, respectively). Inhibitor 7rh reduces DDR1 expression/phosphorylation and downstream signaling in a dose-dependent manner (0.1-2 μM; NCI-H23 NSCLCs), effectively suppressing human cancer cells proliferation (IC50 from 38 nM/K562 to 2.98 μM/NCI-H460) and colony formation (IC50 = 0.56 μM/NCI-H23). Inhibitor 7rh is orally availabe in rats and mice (T1/2 = 15.53 h; Tmax = 4.25 h; Cmax = 1867.5 μg/L, F = 67.4%; 25 mg/kg; rats) and displays in vivo efficacy against Kras (LSLG12Vgeo) tumor growth in mice (50 mg/kg/day p.o.).
storage
Store at -20°C
DDR1-IN-2 Preparation Products And Raw materials
Raw materials
Preparation Products
DDR1-IN-2 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58