5,7-Difluoroindole
- Product Name
- 5,7-Difluoroindole
- CAS No.
- 301856-25-7
- Chemical Name
- 5,7-Difluoroindole
- Synonyms
- SW-101;SWF-101;5,7-difluoroinde;5,8-Difluoroindole;5,7-DIFLUOROINDOLE;5,7-Difluoro-1H-Indole;1H-Indole, 5,7-difluoro-;1H-Indole,5,7-difluoro-(9CI)
- CBNumber
- CB5344431
- Molecular Formula
- C8H5F2N
- Formula Weight
- 153.13
- MOL File
- 301856-25-7.mol
5,7-Difluoroindole Property
- Boiling point:
- 253.2±20.0 °C(Predicted)
- Density
- 1.388±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.71±0.30(Predicted)
- form
- liquid
- color
- Light yellow
- InChI
- InChI=1S/C8H5F2N/c9-6-3-5-1-2-11-8(5)7(10)4-6/h1-4,11H
- InChIKey
- WZPOGQRJXZGSMH-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(F)C=C2F)C=C1
- CAS DataBase Reference
- 301856-25-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D452068
- Product name
- 5,7-Difluoroindole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC7807
- Product name
- 5,7-Difluoro-1H-indole
- Packaging
- 250mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 3H31-3-Q1
- Product name
- 5,7-Difluoro-1H-indole
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- CS-W022280
- Product name
- 5,7-Difluoro-1H-indole
- Purity
- 99.35%
- Packaging
- 250mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- PC7807
- Product name
- 5,7-Difluoro-1H-indole
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
5,7-Difluoroindole Chemical Properties,Usage,Production
Synthesis
500139-00-4
301856-25-7
Example 4: Synthesis of the intermediate 5,7-difluoro-1H-indole To a solution of ethanol (35 mL) containing NaOEt (1.83 g, 26.9 mmol), a solution of ethyl (2,4-difluoro-6-trimethylsilylethynylphenyl)carbamate (2 g, 6.73 mmol) in ethanol (10 mL) was slowly added. The reaction mixture was stirred at room temperature for 1 h (monitored by TLC until the disappearance of the feedstock), followed by refluxing for 1 h. The reaction was completed by cooling to room temperature. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated under vacuum. The residue was dissolved in ether (50 mL) and washed sequentially with dilute hydrochloric acid (3 x 25 mL) and saturated saline (3 x 25 mL). The organic layer was dried with anhydrous Na2SO4, filtered and concentrated in vacuum. Purification by silica gel fast column chromatography (eluent ratio 1:4 ethyl acetate:hexane) gave 770 mg of the title compound in 75% yield.
References
[1] Patent: WO2005/12291, 2005, A1. Location in patent: Page/Page column 63
5,7-Difluoroindole Preparation Products And Raw materials
Raw materials
Preparation Products
5,7-Difluoroindole Suppliers
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