ENALAPRILAT DIHYDRATE
- Product Name
- ENALAPRILAT DIHYDRATE
- CAS No.
- 84680-54-6
- Chemical Name
- ENALAPRILAT DIHYDRATE
- Synonyms
- MK-422;ENALAPRILATE;as dihydrate;ENALAPRILAT USP;MK-422 Dihydrate;Enalaprilate USP25;Vasotec IV Dihydrate;Inapulla (dihydrate);Enalaprilat (300 mg);ENALAPRILAT DIHYDRATE
- CBNumber
- CB5373019
- Molecular Formula
- C18H26N2O6
- Formula Weight
- 366.41
- MOL File
- 84680-54-6.mol
ENALAPRILAT DIHYDRATE Property
- Melting point:
- 151-159°C
- alpha
- [α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble14mg/mL at 60°C (warming for 5 minutes)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- H2O: 14mg/mL at60°C (warming for 5 minutes)
DMSO: 64mg/mL - InChIKey
- MFNXXPRUKGSARH-MTPBSTKNNA-N
- SMILES
- C(N1CCC[C@H]1C(=O)O)(=O)[C@H](C)N[C@H](C(=O)O)CCC1C=CC=CC=1.O |&1:5,10,13,r|
- CAS DataBase Reference
- 84680-54-6(CAS DataBase Reference)
- EPA Substance Registry System
- L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6)
Safety
- WGK Germany
- 3
- RTECS
- TW3590600
- HS Code
- 2933995300
N-Bromosuccinimide Price
- Product number
- Y0000615
- Product name
- Enalaprilat dihydrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 100 mg
- Price
- $156
- Updated
- 2025/07/31
- Product number
- E9658
- Product name
- Enalaprilat dihydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $138
- Updated
- 2025/07/31
- Product number
- PHR3440
- Product name
- Enalaprilat
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 500MG
- Price
- $515
- Updated
- 2025/07/31
- Product number
- BP742
- Product name
- Enalaprilat
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 20MG
- Price
- $245
- Updated
- 2025/07/31
- Product number
- 1235274
- Product name
- Enalaprilat
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 300mg
- Price
- $501
- Updated
- 2025/07/31
ENALAPRILAT DIHYDRATE Chemical Properties,Usage,Production
Description
Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.
Chemical Properties
White Solid
Uses
anthelmintic
Uses
Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor. Enalapril EP Impurity C (Dihydrate).
Definition
ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.
Biochem/physiol Actions
Enalapril, the ethyl ester of?enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to?enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.
References
[1] PIERRE REDELINGHUYS EDWARD D S ALOYSIUS T NCHINDA. Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors[J]. Annals of the New York Academy of Sciences, 2006, 1056 1: 160-175. DOI: 10.1196/annals.1352.035
[2] JAMES J. MENCEL. Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives[J]. Journal of Medicinal Chemistry, 1990, 33 6: 1606-1615. DOI: 10.1021/jm00168a013
ENALAPRILAT DIHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
ENALAPRILAT DIHYDRATE Suppliers
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View Lastest Price from ENALAPRILAT DIHYDRATE manufacturers
- Product
- Enalaprilat Dihydrate 84680-54-6
- Price
- US $0.00/g/Bag
- Min. Order
- 1g
- Purity
- 98%-101%
- Supply Ability
- 500G
- Release date
- 2021-07-19
- Product
- ENALAPRILAT DIHYDRATE 84680-54-6
- Price
- US $32.00-1.30/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-15
- Product
- ENALAPRILAT DIHYDRATE 84680-54-6
- Price
- US $793.70/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 400G
- Release date
- 2021-06-08