ChemicalBook > CAS DataBase List > 5-Fluoro-2-methylphenol

5-Fluoro-2-methylphenol

Product Name: 5-Fluoro-2-methylphenol
CAS No.: 452-85-7
Chemical Name: 5-Fluoro-2-methylphenol
Synonyms: 5-fluoro-o-cresol;5-Fluoro-o-cresol>5-FLUORO-2-METHYLPHENOL;5-Fluoro-o-cresol (OH=1);4-fluoro-2-hydroxytoluene;Phenol, 5-fluoro-2-methyl-;5-Fluoro-2-methylphenol 98%;5-Fluoro-2-methylphenol,98%;4-Fluoro-2-hydroxytoluene 5-Fluoro-2-;4-Fluoro-2-hydroxytoluene, 5-Fluoro-o-cresol
CBNumber: CB5376656
Molecular Formula: C7H7FO
Formula Weight: 126.13
MOL File: 452-85-7.mol

Less

5-Fluoro-2-methylphenol Property

Boiling point:: 66°C 4mm
Density: 1,157 g/cm³
refractive index: 1.514
Flash point:: 66°C/4mm
storage temp.: 2-8°C
form: clear liquid
pka: 9.32±0.10(Predicted)
Specific Gravity: 1.157
color: Colorless to Red to Green
BRN: 3234863
InChI: InChI=1S/C7H7FO/c1-5-2-3-6(8)4-7(5)9/h2-4,9H,1H3
InChIKey: CKJOSIHYVLHIER-UHFFFAOYSA-N
SMILES: C1(O)=CC(F)=CC=C1C
CAS DataBase Reference: 452-85-7(CAS DataBase Reference)

Less

Safety

Hazard Codes: C,T,Xi,Xn
Risk Statements: 36/37/38-22-34-21/22
Safety Statements: 26-36/37/39-45
RIDADR: 3265
Hazard Note: Corrosive/Toxic
HazardClass: IRRITANT, CORROSIVE
HazardClass: 8
HS Code: 29081990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003102
Product name: 5-Fluoro-2-methylphenol
Purity: AldrichCPR
Packaging: 250mg
Price: $68.1
Updated: 2023/01/07

TCI Chemical

Product number: F0632
Product name: 5-Fluoro-o-cresol
Purity: >98.0%(GC)
Packaging: 1g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: F0632
Product name: 5-Fluoro-o-cresol
Purity: >98.0%(GC)
Packaging: 5g
Price: $155
Updated: 2025/07/31

TRC

Product number: F597153
Product name: 5-Fluoro-2-methylphenol
Packaging: 250mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: J55821
Product name: 5-Fluoro-2-methylphenol
Packaging: 1g
Price: $10
Updated: 2021/12/16

Less

5-Fluoro-2-methylphenol Chemical Properties,Usage,Production

Chemical Properties

Colorless transparent liquid

Uses

5-Fluoro-2-methylphenol is a phenolic compound with methyl and fluorine atom substituents at the 2 and 5 positions. It is widely used as a raw material for the preparation of other organic compounds or pharmaceutical intermediates.

Synthesis

367-29-3

452-85-7

1. Prepare a hot sulfuric acid solution by slowly adding 7 mL of concentrated sulfuric acid to 21 mL of water. To 5-fluoro-2-methylaniline (5 g, 40 mmol) was added the above hot sulfuric acid solution. 2. The reaction mixture was cooled in an ice bath for 30 minutes, followed by the dropwise addition of a 10 mL aqueous solution of sodium nitrite (3.38 g, 48 mmol) over 10 minutes. 3. After continuous stirring at 0 °C for 45 min, the reaction mixture was diluted with 20 mL of cold water and treated with 0.3 g of urea. 4. the resulting mixture was slowly added to a pre-stirred solution of 11 mL of concentrated sulfuric acid with 10 mL of water (containing 15 g of anhydrous sodium sulfate) over a period of 10 minutes, maintaining the reaction temperature at 130 °C. the reaction was continued at 0 °C for a period of 45 minutes with continuous stirring. 5. After continuing the reaction at 130 °C for 5 minutes, the reaction was cooled to room temperature and extracted with three 100 mL dichloromethane. 6. The organic layers were combined and washed with two parts 50 mL of water and subsequently concentrated under vacuum. 7. The resulting slightly reddish oil was dissolved in 250 mL of ether and washed with three parts of 50 mL of 10% aqueous sodium hydroxide. 8. The aqueous sodium hydroxide extracts were combined and washed with two 50 mL portions of diethyl ether. 9. Acidify the basic layer with aqueous 1N HCl followed by extraction with three 100 mL dichloromethane. 10. The dichloromethane layers were combined, washed with two 50 mL portions of brine, dried over sodium sulfate, filtered and concentrated in vacuum to give a light red liquid. 11. The crude product was purified by silica gel column chromatography (eluent: hexane solution of 10% ethyl acetate) to give 5 g of 5-fluoro-2-methylphenol as a light brown oil (99% yield). 12. 5-fluoro-2-methylphenol (640 mg, 5 mmol) was dissolved in 20 mL of anhydrous acetonitrile, cooled to -30 °C to -40 °C, and nitronium tetrafluoroborate (740 mg, 5.5 mmol) was added. 13. After 45 minutes of reaction, the reaction mixture was diluted with 100 mL of cold water and extracted with three 50 mL portions of dichloromethane. 14. The organic layers were combined, washed with three 25 mL water, dried over sodium sulfate and concentrated in vacuum to give a reddish crystalline solid. 15. purification by silica gel column chromatography (eluent: hexane solution of 5% ethyl acetate) to give 0.58 g of the target product as a bright yellow solid (68% yield). 16. Conversion of the target compound to the corresponding trifluoromethanesulfonate according to the method described in Example 26.

References

[1] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 184-185
[2] Tetrahedron, 1959, vol. 6, p. 315,316
[3] Patent: US2003/207924, 2003, A1

5-Fluoro-2-methylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5-Fluoro-2-methylphenol Suppliers

Americas 1 Belgium 1 China 144 Europe 1 France 2 Germany 5 India 8 Italy 1 Japan 2 The Netherlands 1 United Kingdom 22 United States 35 Global 223

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16077
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Beijing Eternalchem Co,. Ltd.

Tel: 010-59484199 18611897322
Email: sales@eternalchem.com
Country: China
ProdList: 4383
Advantage: 60

PSN Pharmaceutical Technology Co., Ltd.

Tel: 86-25-57062118
Fax: 86-25-57065896
Email: sales@jspsn.com
Country: China
ProdList: 496
Advantage: 57

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Tianjin Jinyuda Chemical Co., Ltd.

Tel: 022-58013646 13011382049
Fax: 022-23854368
Email: sales@jinyudachem.com
Country: China
ProdList: 1930
Advantage: 55

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 1490
Advantage: 62

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Hangzhou Dechem Tech Co.，Ltd

Tel: 86-0571-87649320
Fax: 86-0571-87649320
Email: dechem@aliyun.com
Country: China
ProdList: 162
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Chongqing Kangheyuecheng Pharmaceutical Technology Co., Ltd.

Tel: 023-61183015; 13271886913
Email: kangheyuecheng@163.com
Country: China
ProdList: 292
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Beijing Hechemist Technology CO.,LTD

Tel: 18511709189
Fax: 010-58043593
Email: sales@hechemist.com
Country: China
ProdList: 2835
Advantage: 58

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9942
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Less

View Lastest Price from 5-Fluoro-2-methylphenol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Fluoro-2-methylphenol 452-85-7
Price: US $40.00-20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-05

Career Henan Chemical Co

Product: 5-Fluoro-2-methylphenol 452-85-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

452-85-7, 5-Fluoro-2-methylphenolRelated Search:

m-Cresol Cresol 3-(Trifluoromethyl)benzaldehyde 4-Fluorophenol o-Cresol p-Cresol 3-Ethylphenol Xylenol 2,6-Dimethylphenol Fluorine 4-FLUORO-2-HYDROXYBENZOIC ACID 4-Fluoro-2-methoxybenzoic acid 4-FLUORO-2-METHOXYACETOPHENONE 4'-Fluoro-2'-hydroxyacetophenone 4-FLUORO-2-METHOXYBENZALDEHYDE 3,4-Difluoro-2-methoxybenzoic acid 5-FLUORO-2-METHYLANISOLE 4-Fluoro-3-methylphenol 98%,4-Fluoro-3-methylphenol98%,4-FLUORO-3-METHYLPHENOL

5-FLUORO-2-METHYLPHENOL

5-Fluoro-2-methylphenol,98%

4-fluoro-2-hydroxytoluene

5-fluoro-o-cresol

5-Fluoro-2-methylphenol 98%

5-Fluoro-o-cresol (OH=1)

4-Fluoro-2-hydroxytoluene, 5-Fluoro-o-cresol

4-Fluoro-2-hydroxytoluene 5-Fluoro-2-

4-Fluoro-2-hydroxytoluene 5-Fluoro-2-methylphenol

5-Fluoro-o-cresol&gt

Phenol, 5-fluoro-2-methyl-

452-85-7

2-85-7

Phenol&Thiophenol&Mercaptan

Fluorine Compounds

Phenols

Aromatic Phenols