HUMAN IL-13
Description Source Background- Product Name
- HUMAN IL-13
- CAS No.
- 148157-34-0
- Chemical Name
- HUMAN IL-13
- Synonyms
- ALRH;BHR1;P600;NC30;IL-13;RHIL-13;HUMAN NC30;Aids059207;HUMAN IL-13;Aids-059207
- CBNumber
- CB5431133
- Formula Weight
- 0
- MOL File
- Mol file
HUMAN IL-13 Property
- storage temp.
- -20°C
- form
- lyophilized powder
- color
- white to off-white
- biological source
- rat
N-Bromosuccinimide Price
- Product number
- SRP4166
- Product name
- IL-13 from rat
- Purity
- recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
- Packaging
- 10μG
- Price
- $356
- Updated
- 2025/07/31
- Product number
- SRP3241
- Product name
- IL-13 Long Form from rat
- Purity
- recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 10μG
- Price
- $356
- Updated
- 2025/07/31
- Product number
- SRP3076
- Product name
- IL-13 Variant human
- Purity
- recombinant, expressed in <I>E. coli</I>, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 10 μg
- Price
- $356
- Updated
- 2025/07/31
- Product number
- I1896
- Product name
- Interleukin-13 from mouse
- Purity
- ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
- Packaging
- 5μG
- Price
- $602
- Updated
- 2025/07/31
- Product number
- I1771
- Product name
- Interleukin-13 human
- Purity
- ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
- Packaging
- 10μg
- Price
- $418.6
- Updated
- 2025/07/31
HUMAN IL-13 Chemical Properties,Usage,Production
Uses
IL-13 variant human has been used for the treatment of THP1 monocytes, along with with IL-4 and phorbol myristate acetate (PMA), to study the ability of SFN (sulforaphane) to induce THP1 differentiation into M2 macrophage cells.
General Description
Interleukin-13 (IL-13) is an immunoregulatory cytokine produced primarily by activated T-helper 2 (Th2) cells,and also by mast cells and natural killer (NK) cells. The gene encoding it is localized on human chromosome 5q31. Human and murine IL-13 is cross-species reactive. Recombinant human IL-13 is a 12.6kDa protein consisting of 115 amino acid residues.
Biochem/physiol Actions
Interleukin-13 (IL-13) has a role in immune activities against infections and influences the function of various cells taking part in the same. It has been studied to be overexpressed in glioblastoma tumors and cell lines. IL-13 stimulates fibrosis in many infectious diseases. Targeted deletion of IL-13 in mice resulted in impaired T-helper 2 (Th2) cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukins-1β, -6 and -8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of immunoglobulin E (IgE). Blocking of IL-13 activity inhibits the pathophysiology of asthma.
Description
Interleukin-13 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 112 amino acids and having a molecular mass of 12 kDa.
The IL-13 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
HUMAN IL-13 Preparation Products And Raw materials
Raw materials
Preparation Products
HUMAN IL-13 Suppliers
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82