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PF-05089771 (tosylate)

Product Name
PF-05089771 (tosylate)
CAS No.
1430806-04-4
Chemical Name
PF-05089771 (tosylate)
Synonyms
PF0508977;PF-05089771 (tosylate);PF-05089771 >=98% (HPLC);4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate;4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide, monomethylbenzenesulfonate;PF 05089771 tosylate,TTX-R,pain,Na channels,PF-05089771,neuropathy,diabetic,Sodium Channel,PF05089771,inhibit,PF 05089771,tetrodotoxin,Na+ channels,Inhibitor
CBNumber
CB54666201
Molecular Formula
C25H20Cl2FN5O6S3
Formula Weight
672.5556032
MOL File
1430806-04-4.mol
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PF-05089771 (tosylate) Property

storage temp. 
room temp
solubility 
DMF: 33 mg/ml; DMSO: 33 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form 
powder
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0311
Product name
PF-05089771
Purity
≥98% (HPLC)
Packaging
5MG
Price
$105
Updated
2023/06/20
Sigma-Aldrich
Product number
PZ0311
Product name
PF-05089771
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/06/20
Cayman Chemical
Product number
24449
Product name
PF-05089771 (tosylate)
Purity
≥98%
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
24449
Product name
PF-05089771 (tosylate)
Purity
≥98%
Packaging
10mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
24449
Product name
PF-05089771 (tosylate)
Purity
≥98%
Packaging
25mg
Price
$389
Updated
2024/03/01
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PF-05089771 (tosylate) Chemical Properties,Usage,Production

Description

PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50s = ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50s = 10 and 20 μM, respectively). PF-05089771 is also 1,000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation of the domain IV voltage-sensor domain (VSD4) reduces PF-05089771 potency by approximately 100-fold.

Biochem/physiol Actions

PF-05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. PF-05089771 targets the voltage-sensing domain, preferentially interacting with, and stabilizing, inactivated channel conformations by interaction with the voltage-sensor domain (VSD) of Domain 4. Nav1.7 is expressed in sensory neurons and is critical for pain processing. PF-05089771 is being investigated for the treatment of chronic neuropathic pain.

storage

Desiccate at RT

PF-05089771 (tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-05089771 (tosylate) Suppliers

China 16 United Kingdom 1 United States 5 USA 1 Global 23
Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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010-50973130 4009686088
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216895
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sales@hzclap.com
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DC Chemicals
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021-58447131 13564518121
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sales@dcchemicals.com
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China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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Energy Chemical
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marketing@energy-chemical.com
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China
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Changzhou Furuisi Biotechnology Co., Ltd
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0519-85524369
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3477467573@qq.com
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Hebei Weite Medical Technology Co., Ltd
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13180081292
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contact@wetogethermed.com
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China
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Nantong Hi-Future Biotechnology Co., Ltd
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18051384581
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sales@chemhifuture.com
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InvivoChem
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13549236410
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sales@invivochem.cn
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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025-85563444
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cindy.huang@synzest.com
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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+86-18521732826
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market@aladdin-e.com
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Shaanxi Istare Biotechnology Co., Ltd.
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Nantong HI-FUTURE Biology Co., Ltd.
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sales@chemhifuture.com
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1430806-04-4, PF-05089771 (tosylate)Related Search:

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  • PF-05089771 (tosylate)
  • 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate
  • PF-05089771 >=98% (HPLC)
  • PF 05089771 tosylate,TTX-R,pain,Na channels,PF-05089771,neuropathy,diabetic,Sodium Channel,PF05089771,inhibit,PF 05089771,tetrodotoxin,Na+ channels,Inhibitor
  • PF0508977
  • 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide, monomethylbenzenesulfonate
  • 1430806-04-4