ChemicalBook > CAS DataBase List > RU-301

RU-301

Product Name
RU-301
CAS No.
1110873-99-8
Chemical Name
RU-301
Synonyms
RU-301;RU 301;RU301;RU-301, 10 mM in DMSO;inhibit,TAM,RU-301,NASH,cancer,TAM Receptor,Gas6,Axl,RU301,Inhibitor,RU 301,Tyro3,Mer,H1299,TGFβ1,ERK;2-(((3-Methylisoxazol-5-yl)methyl)thio)-N-(2-((3-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide;Benzamide, 2-[[(3-methyl-5-isoxazolyl)methyl]thio]-N-[2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethyl]-;2-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}-N-(2-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethyl)benzamide
CBNumber
CB54668467
Molecular Formula
C21H19F3N4O4S
Formula Weight
480.46
MOL File
1110873-99-8.mol
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RU-301 Property

Boiling point:
661.0±55.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (520.33 mM)
form 
Solid
pka
13.86±0.46(Predicted)
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
25mg
Price
$990
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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RU-301 Chemical Properties,Usage,Production

Uses

RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site.

in vivo

RU-301 (100, 300 mg/kg; i.p.; single daily for 4 days) inhibits tumor growth in lung cancer xenograft model[1].
RU-301 (300 mg/kg; i.p.; 3 times a week for 4 weeks) reduces liver fibrosis in mice[2].

Animal Model:NOD/SCIDγ mice (4-6 week; lung cancer xenograft model)[1].
Dosage:100, 300 mg/kg
Administration:Intraperitoneal injection; single daily for 4 days
Result:Significantly decreased tumor volume while body weights were not significantly different.
Showed no notable toxicity but displayed good bioavailability with a t1/2 life of ~7-8 hours.
Animal Model:WT or Mertk?/? male mice (fed NASH diet for 12 weeks)[2].
Dosage:300 mg/kg
Administration:Intraperitoneal injection; 3 times a week for 4 weeks
Result:Reduced liver fibrosis as indicated by decreases in liver picrosirius red staining and collagen gene expression.

RU-301 Preparation Products And Raw materials

Raw materials

Preparation Products

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RU-301 Suppliers

China 33 United States 3 Global 36
Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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028-81705658
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3003855609@qq.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
ProdList
8000
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
Fax
21-5161 9052
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Sales@ATKchemical.com
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China
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9119
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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CHINA
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Shanghai Dongyang Biotechnology Co., Ltd.
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0512-0512-13601744364 13601744364
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chemsharker@126.com
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China
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Changzhou Chenhong Biotechnology Co., Ltd.
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+86-0519-85788828 +86-13775037613
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sales@chemrenpharm.com
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China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
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China
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Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
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021-51816796-820 13611835272
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021-5161 3951
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sales2@sunwaypharm.com
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China
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Jinan Jiuli Biotechnology Co. , Ltd.
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15865264761
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486064515@qq.com
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China
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InvivoChem
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13549236410
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sales@invivochem.cn
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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https://hanhongsci.com/
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021-54306202 18917919676
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info@hanhongsci.com
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Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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021-59167510 18117107507
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vip@med-life.cn
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China
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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China
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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400-6206333 13167063860
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anhua.mao@aladdin-e.com
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China
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
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025-58851090 17714375163
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2881759498@qq.com
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China
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Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026
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Sales@sangon.com
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Biosynth Biological Technology (Suzhou) Co Ltd
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sales@biosynth.com
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Adooq Bioscience LLC
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Selleck Chemicals
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ATK CHEMICAL COMPANY LIMITED
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Lingmei Experimental Instruments (Shanghai) Co., Ltd.
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15356162092
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Tianjin Baibei Biotechnology Co., Ltd.
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Guangzhou Bingheng Biotechnology Co., Ltd.
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Guangzhou Chuangze Biotechnology Co., Ltd.
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Biorbyt Ltd.
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Absin Bioscience Inc.
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Proteintech China
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1110873-99-8, RU-301Related Search:


  • RU-301
  • RU 301;RU301
  • Benzamide, 2-[[(3-methyl-5-isoxazolyl)methyl]thio]-N-[2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethyl]-
  • inhibit,TAM,RU-301,NASH,cancer,TAM Receptor,Gas6,Axl,RU301,Inhibitor,RU 301,Tyro3,Mer,H1299,TGFβ1,ERK
  • RU-301, 10 mM in DMSO
  • 2-(((3-Methylisoxazol-5-yl)methyl)thio)-N-(2-((3-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide
  • 2-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}-N-(2-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethyl)benzamide
  • 1110873-99-8