ChemicalBook > CAS DataBase List > RU-301

RU-301

Product Name
RU-301
CAS No.
1110873-99-8
Chemical Name
RU-301
Synonyms
RU-301;RU 301;RU301;RU-301, 10 mM in DMSO;inhibit,TAM,RU-301,NASH,cancer,TAM Receptor,Gas6,Axl,RU301,Inhibitor,RU 301,Tyro3,Mer,H1299,TGFβ1,ERK;2-(((3-Methylisoxazol-5-yl)methyl)thio)-N-(2-((3-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide;Benzamide, 2-[[(3-methyl-5-isoxazolyl)methyl]thio]-N-[2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethyl]-;2-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}-N-(2-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethyl)benzamide
CBNumber
CB54668467
Molecular Formula
C21H19F3N4O4S
Formula Weight
480.46
MOL File
1110873-99-8.mol
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RU-301 Property

Boiling point:
661.0±55.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (520.33 mM)
form 
Solid
pka
13.86±0.46(Predicted)
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
25mg
Price
$990
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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RU-301 Chemical Properties,Usage,Production

Uses

RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site.

in vivo

RU-301 (100, 300 mg/kg; i.p.; single daily for 4 days) inhibits tumor growth in lung cancer xenograft model[1].
RU-301 (300 mg/kg; i.p.; 3 times a week for 4 weeks) reduces liver fibrosis in mice[2].

Animal Model:NOD/SCIDγ mice (4-6 week; lung cancer xenograft model)[1].
Dosage:100, 300 mg/kg
Administration:Intraperitoneal injection; single daily for 4 days
Result:Significantly decreased tumor volume while body weights were not significantly different.
Showed no notable toxicity but displayed good bioavailability with a t1/2 life of ~7-8 hours.
Animal Model:WT or Mertk?/? male mice (fed NASH diet for 12 weeks)[2].
Dosage:300 mg/kg
Administration:Intraperitoneal injection; 3 times a week for 4 weeks
Result:Reduced liver fibrosis as indicated by decreases in liver picrosirius red staining and collagen gene expression.

RU-301 Preparation Products And Raw materials

Raw materials

Preparation Products

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RU-301 Suppliers

China 33 United States 3 Global 36
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
42446
Advantage
60
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1010
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58

1110873-99-8, RU-301Related Search:


  • RU-301
  • RU 301;RU301
  • Benzamide, 2-[[(3-methyl-5-isoxazolyl)methyl]thio]-N-[2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethyl]-
  • inhibit,TAM,RU-301,NASH,cancer,TAM Receptor,Gas6,Axl,RU301,Inhibitor,RU 301,Tyro3,Mer,H1299,TGFβ1,ERK
  • RU-301, 10 mM in DMSO
  • 2-(((3-Methylisoxazol-5-yl)methyl)thio)-N-(2-((3-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide
  • 2-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}-N-(2-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethyl)benzamide
  • 1110873-99-8