ChemicalBook > CAS DataBase List > RU-301

RU-301

Product Name
RU-301
CAS No.
1110873-99-8
Chemical Name
RU-301
Synonyms
RU-301;RU 301;RU301;RU-301, 10 mM in DMSO;inhibit,TAM,RU-301,NASH,cancer,TAM Receptor,Gas6,Axl,RU301,Inhibitor,RU 301,Tyro3,Mer,H1299,TGFβ1,ERK;2-(((3-Methylisoxazol-5-yl)methyl)thio)-N-(2-((3-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide;Benzamide, 2-[[(3-methyl-5-isoxazolyl)methyl]thio]-N-[2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethyl]-;2-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}-N-(2-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethyl)benzamide
CBNumber
CB54668467
Molecular Formula
C21H19F3N4O4S
Formula Weight
480.46
MOL File
1110873-99-8.mol
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RU-301 Property

Boiling point:
661.0±55.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 250 mg/mL (520.33 mM)
form 
Solid
pka
13.86±0.46(Predicted)
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
25mg
Price
$990
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0066591
Product name
RU-301
Purity
99.73%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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RU-301 Chemical Properties,Usage,Production

Uses

RU-301 is a pan-TAM receptor (Axl, Tyro3 and Mertk) inhibitor that blocks the Axl receptor dimerization site.

in vivo

RU-301 (100, 300 mg/kg; i.p.; single daily for 4 days) inhibits tumor growth in lung cancer xenograft model[1].
RU-301 (300 mg/kg; i.p.; 3 times a week for 4 weeks) reduces liver fibrosis in mice[2].

Animal Model:NOD/SCIDγ mice (4-6 week; lung cancer xenograft model)[1].
Dosage:100, 300 mg/kg
Administration:Intraperitoneal injection; single daily for 4 days
Result:Significantly decreased tumor volume while body weights were not significantly different.
Showed no notable toxicity but displayed good bioavailability with a t1/2 life of ~7-8 hours.
Animal Model:WT or Mertk?/? male mice (fed NASH diet for 12 weeks)[2].
Dosage:300 mg/kg
Administration:Intraperitoneal injection; 3 times a week for 4 weeks
Result:Reduced liver fibrosis as indicated by decreases in liver picrosirius red staining and collagen gene expression.

RU-301 Preparation Products And Raw materials

Raw materials

Preparation Products

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RU-301 Suppliers

China 33 United States 3 Global 36
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58

1110873-99-8, RU-301Related Search:


  • RU-301
  • RU 301;RU301
  • Benzamide, 2-[[(3-methyl-5-isoxazolyl)methyl]thio]-N-[2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethyl]-
  • inhibit,TAM,RU-301,NASH,cancer,TAM Receptor,Gas6,Axl,RU301,Inhibitor,RU 301,Tyro3,Mer,H1299,TGFβ1,ERK
  • RU-301, 10 mM in DMSO
  • 2-(((3-Methylisoxazol-5-yl)methyl)thio)-N-(2-((3-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide
  • 2-{[(3-methyl-1,2-oxazol-5-yl)methyl]sulfanyl}-N-(2-{[2-nitro-4-(trifluoromethyl)phenyl]amino}ethyl)benzamide
  • 1110873-99-8