CINPA 1

Product Name: CINPA 1
CAS No.: 102636-74-8
Chemical Name: CINPA 1
Synonyms: CINPA 1;CINPA1, 10 mM in DMSO;Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate;Carbamic acid, N-[5-[2-(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester;Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI);ethyl N-{2-[2-(diethylamino)acetyl]-2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl}carbamate
CBNumber: CB54723186
Molecular Formula: C23H29N3O3
Formula Weight: 395.49
MOL File: 102636-74-8.mol

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CINPA 1 Property

Boiling point:: 545.8±50.0 °C(Predicted)
Density: 1.179±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 100 mM; Ethanol: 100 mM
form: A crystalline solid
pka: 13.44±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29110
Product name: CINPA1
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29110
Product name: CINPA1
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29110
Product name: CINPA1
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Tocris

Product number: 5605
Product name: CINPA1
Purity: ≥98%(HPLC)
Packaging: 10
Price: $124
Updated: 2021/12/16

Tocris

Product number: 5605
Product name: CINPA1
Purity: ≥98%(HPLC)
Packaging: 50
Price: $521
Updated: 2021/12/16

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CINPA 1 Chemical Properties,Usage,Production

Uses

CINPA 1 is an inhibitor of constitutive androstane receptor (CAR) which regulates the expression of genes involved in drug metabolism.

Biological Activity

CINPA1 is a ligand-binding domain (LBD)-targeting constitutive androstane receptor (CAR) inhibitor th at prevents CAR recruitment to promoter regions of regulated genes (by >85%; 1 μM CINPA1 against 0.1 μM CITCO-induced CAR recruitment to CYP2B6 or CYP3A4 promoters; human hepatocytes) by altering CAR-coregulator interactions. CINPA1 inhibits CAR-mediated transcription in a potent (IC50 = 70 nM; HepG2-hCAR1 CYP2B6-luc reporter cells) and selective manner with only weak PXR antagonist potency (68% inhibition by 18 μM CINPA1 against 5 μM rifampicin; HepG2-PXR reporter cells) and no cytotoxicity or agonist/antagonist activity toward FXR, GR, LXRα/β, PPARγ, RXRα/β, VDR.

storage

Store at -20°C

CINPA 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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CINPA 1 Suppliers

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102636-74-8, CINPA 1Related Search:

CINPA 1

Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate

Carbamic acid, [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester (9CI)

Carbamic acid, N-[5-[2-(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-, ethyl ester

ethyl N-{2-[2-(diethylamino)acetyl]-2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3(8),4,6,12,14-hexaen-5-yl}carbamate

CINPA1, 10 mM in DMSO

102636-74-8