Fosamprenavir calcium
- Product Name
- Fosamprenavir calcium
- CAS No.
- 226700-81-8
- Chemical Name
- Fosamprenavir calcium
- Synonyms
- Telzir;Lexiva;GW-433908G;FOSAMPRENAVIR;GW-433908;GW-433908G;fosamprenavir calcium;FOSAMPRENAVIR, CALCIUM SALT;Fosamprenavir Calcium (200 mg);Fosamprenavir Calcium (GW433908G);Fosamprenavir & Fosamprenavir Calcium
- CBNumber
- CB5496914
- Molecular Formula
- C25H34CaN3O9PS
- Formula Weight
- 623.668921
- MOL File
- 226700-81-8.mol
Fosamprenavir calcium Property
- Melting point:
- 282-2840C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Aqueous Acid (Slightly), DMF (Slightly)
- form
- Solid
- color
- White to Off-White
- BCS Class
- 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21609
- Product name
- Fosamprenavir (calcium salt)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 21609
- Product name
- Fosamprenavir (calcium salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 21609
- Product name
- Fosamprenavir (calcium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $768
- Updated
- 2024/03/01
- Product number
- 21609
- Product name
- Fosamprenavir (calcium salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $1151
- Updated
- 2024/03/01
- Product number
- F6035
- Product name
- Fosamprenavir Calcium Salt
- Packaging
- 1mg
- Price
- $496
- Updated
- 2021/12/16
Fosamprenavir calcium Chemical Properties,Usage,Production
Description
Fosamprenavir (calcium salt) is an orally bioavailable prodrug of the HIV-1 protease inhibitor amprenavir . Fosamprenavir has improved solubility compared with amprenavir, and its pharmacokinetics, either during fasting or with a low- or high-fat meal, suggest that it could be effective using fewer tablets and a less complex dosing schedule than other HIV treatments. Formulations containing fosamprenavir are used for adult and pediatric patients with HIV infection, especially as an initial antiretroviral therapy.
Description
Fosamprenavir, a prodrug of the HIV protease inhibitor amprenavir, is indicated for the oral treatment of HIV infection in adults in combination with other antiretroviral agents. Although amprenavir has excellent antiviral potency and good tolerability, its watersolubility is poor (0.04 mg/ml). As a result, the formulation of the agent includes a high percentage of organic excipients to facilitate gastric dissolution, which limits the amount of active drug that can be formulated per capsule. Fosamprenavir is a highly soluble phosphate ester of amprenavir. It allows more convenient dosing and reduction in pill counts as compared to amprenavir. Fosamprenavir is readily prepared in two steps starting from a key intermediate used in the synthesis of amprenavir, by phosphorylating a hydroxyl group and subsequently reducing a p-nitrophenyl to a p-aminophenyl group. Fosamprenavir has little or no antiviral activity in vitro. After oral administration, it is rapidly and almost completely hydrolyzed by phosphatases in the gut epithelium to amprenavir prior to reaching systemic circulation. The time to reach peak plasma concentration of amprenavir is approximately 2.5 h and the plasma elimination half-life is approximately 7.7 h. Amprenavir is metabolized in the liver by CYP3A4 and ＞90% of the dose is excreted as metabolites in urine and feces. In most patients, fosamprenavir is administered at daily doses of 700–1400 mg in conjunction with ritonavir. Monotherapy with fosamprenavir is only recommended in antiretroviral therapy-na?ve patients and the dosing regimen is 1400 mg twice daily. The most common adverse events experienced with fosamprenavir are diarrhea, nausea, vomiting, headache and rash.
Chemical Properties
White Microcrystalline Needles
Originator
Vertex (US)
Uses
HIV protease inhibitor; water soluble prodrug of amprenavir.
Uses
Protease inhibitor, anti-HIV agent
brand name
Lexiva (GlaxoSmithKline).
General Description
Fosamprenavir is used in combination with otherHIV drugs in adult patients. Like the other PIs, this compoundis a prodrug that produces the active drug uponhydrolysis. In this case, the active drug is amprenavir, apeptidomimetic transition state inhibitor. Fosamprenaviris typically administered in combination with RTinhibitors.
Clinical Use
Fosamprenavir calcium has been approved for the treatment of HIV in adults when used in combination with other anti-HIV drugs. It is a prodrug that, on hydrolysis by serum phosphatases, gives rise to amprenavir, which is a peptidomimetic transition-state inhibitor that targets HIV-1 protease and reduces the viral replication and, thus, the infectiousness of HIV-1. It is commonly administered in combination with RT inhibitors to produce excellent efficacy in patients with AIDS. The drug is administered as two 700 mg tablets twice daily or, in combination with ritonavir, can be given as two 700 mg tables once daily or one 700 mg tablet twice daily. As a result, formaprenavir lowers the "pill burden" in patients with AIDS.
Synthesis
The synthesis of fosamprenavir (X) started with a known amino alcohol 91. N,N-Dibenzyl-L-phenylalaninal (87) was prepared by reduction of L-phenylalanine (86) to L-phenylalaninol followed by N,N-dibenzylation and oxidation to the aldehyde 87 using pyridine-sulfur trioxide complex at room temperature. A large excess of lithium shot was stirred in a solution of aldehyde 87 and bromochloromethane in THF at -65??C. The reaction mixture was subsequently allowed to warm up to room temperature to provide the diastereomeric epoxide mixture (6:1) which was quenched with 6N aqueous HCl and set standing overnight to provide the salt precipitate. Recrystallization from methanol gave optically pure dibenzylaminochlorohydrin hydrochloride (88) in 38- 45% yield. Hydrogenolysis under standard conditions gave deprotected aminochlorohydrin hydrochloride 89 as a crystalline white solid. Conversion to desired N-Bocepoxide 90 was accomplished by the introduction of the Boc group followed by cyclization. N-Boc-epoxide 90 was then converted to amino alcohol 91 by refluxing with isobutylamine in EtOH. Treatment of the amino alcohol91 with p-nitrobenzene sulphonyl chloride in toluene at 80??C followed by acid hydrolysis of the Boc group furnished sulphonamide 93 in 73% yield. The carbamate 95 was prepared by refluxing 93 with (S)-tetrahydrofuryl imidazole carboxylate (94) in EtOAc. Treatment of the sulphonamide 95 with POCl3 followed by aqueous HCl hydrolysis provided the phosphate intermediate, which was then reduced by hydrogenation and converted to fosamprenavir calcium salt X in a one-pot process in 92% yield.
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: possibly increased concentration
of amiodarone, flecainide, lidocaine and propafenone
(increased risk of ventricular arrhythmias) - avoid.
Antibacterials: increases concentration of rifabutin
- reduce rifabutin dose; concentration significantly
reduced by rifampicin - avoid; avoid with
telithromycin in severe renal and hepatic impairment.
Anticoagulants: avoid with apixaban and
rivaroxaban.
Antidepressants: concentration reduced by St John’s
wort - avoid.
Antimalarials: use artemether/lumefantrine with
caution; possibly increases quinine concentration.
Antipsychotics: possibly inhibits aripiprazole
metabolism - reduce aripiprazole dose; possibly
increases quetiapine concentration - avoid; possibly
increases pimozide concentration (increased risk of
ventricular arrhythmias) - avoid.
Antivirals: avoid with boceprevir, raltegravir and
telaprevir; concentration of dolutegravir reduced;
concentration increased by etravirine, consider
reducing fosamprenavir dose; concentration
reduced by lopinavir, maraviroc and tipranavir,
effect on lopinavir unpredictable - avoid, avoid
with maraviroc; concentration possibly reduced by
nevirapine; avoid with raltegravir.
Anxiolytics and hypnotics: increased risk of
prolonged sedation and respiratory depression with
midazolam - avoid with oral midazolam.
Avanafil: concentration of avanafil possibly increased.
Cytotoxics: possibly increases concentration of
bosutinib and ibrutinib, avoid or consider reducing
bosutinib and ibrutinib dose.
Ergot alkaloids: increased risk of ergotism - avoid.
Immunosuppressants: monitor ciclosporin,
tacrolimus and sirolimus levels.
Lomitapide: avoid concomitant use.
Orlistat: absorption possibly reduced by orlistat.
Ranolazine: possibly increases ranolazine
concentration - avoid.
Statins: possibly increased risk of myopathy with
atorvastatin; possibly increased myopathy with
simvastatin and rosuvastatin - avoid.
Metabolism
Fosamprenavir is rapidly and almost completely hydrolysed to amprenavir and inorganic phosphate as it is absorbed through the gut epithelium, following oral administration. The primary route of metabolism of amprenavir is via the cytochrome P450 3A4 enzyme. The primary route of elimination of amprenavir is via hepatic metabolism with less than 1% excreted unchanged in the urine and no detectable amprenavir in faeces. Metabolites account for approximately 14% of the administered amprenavir dose in the urine, and approximately 75% in the faeces.
References
[1]. wire, m.b., et al., pharmacokinetics and safety of gw433908 and ritonavir, with and without efavirenz, in healthy volunteers. aids, 2004. 18(6): p. 897-907.
[2]. hamada, y., et al., high incidence of renal stones among hiv-infected patients on ritonavir-boosted atazanavir than in those receiving other protease inhibitor-containing antiretroviral therapy. clin infect dis, 2012. 55(9): p. 1262-9.
[3]. zheng, y., et al., antiretroviral therapy and efficacy after virologic failure on first-line boosted protease inhibitor regimens. clin infect dis, 2014. 59(6): p. 888-96.
[4]. falcoz, c., et al., pharmacokinetics of gw433908, a prodrug of amprenavir, in healthy male volunteers. j clin pharmacol, 2002. 42(8): p. 887-98.
Fosamprenavir calcium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fosamprenavir calcium manufacturers
- Product
- Fosamprenavir calcium 226700-81-8
- Price
- US $5.00-450.00/G
- Min. Order
- 1G
- Purity
- 99.99%
- Supply Ability
- 1000kg
- Release date
- 2022-11-04
- Product
- Fosamprenavir Calcium Salt 226700-81-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Fosamprenavir Calcium Salt 226700-81-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09