4-Chloro-1H-pyrazolo[3,4-d]pyrimidine

Product Name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
CAS No.: 5399-92-8
Chemical Name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
Synonyms: NSC 4937;oro-1H-pyrazoL;AKOS BBS-00002106;o[3,4-d]pyrimidine;IFLAB-BB F0909-0060;4-chloro-1H-pyrazolo[3;Ibrutinib Impurity 115;4-Chloropyrazolo[3,4-d]pyrimidine;4-CHLORO-1H-PYRAZOLO3,4-DPYRIMIDINE;4-chloro-1H-pyrazolo[4,3-e]pyrimidine
CBNumber: CB5668331
Molecular Formula: C5H3ClN4
Formula Weight: 154.56
MOL File: 5399-92-8.mol

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4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Property

Melting point:: >350?C
Boiling point:: 224.6±50.0 °C(Predicted)
Density: 1.84±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 10.16±0.20(Predicted)
color: Yellow to Orange
CAS DataBase Reference: 5399-92-8(CAS DataBase Reference)

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Safety

Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C379915
Product name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
Packaging: 5g
Price: $235
Updated: 2021/12/16

TRC

Product number: C379915
Product name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
Packaging: 10g
Price: $400
Updated: 2021/12/16

Usbiological

Product number: 006660
Product name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
Packaging: 250mg
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0023285
Product name: 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
Purity: 95.00%
Packaging: 250MG
Price: $750.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0023285
Product name: 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
Purity: 95.00%
Packaging: 2.5G
Price: $2035
Updated: 2021/12/16

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4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Has a SK channel blocker effect.

Synthesis

5305-40-8

5399-92-8

Synthesis of compound 4.1. Hydrazine hydrate (11.5 mL, 23.7 mmol) was slowly added dropwise to a 1,4-dioxane solution (600 mL) containing 4,6-dichloro-5-pyrimidinecarboxaldehyde (40.0 g, 22.6 mmol) and triethylamine (30 mL, 22 mmol) under the cooling of an ice bath, and the temperature of the reaction was controlled to be no more than 20°C. The reaction temperature was controlled to be no higher than 20°C. After dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the precipitate was collected by filtration. The filtrate was concentrated under reduced pressure to give compound 4.1 (29 g, 83% yield) in the form of a light yellow solid. The product was characterized by 1H NMR (400.13 MHz, DMSO-d6) and mass spectrometry: 1H NMR δ 14.52 (br.s, 1H), 8.83 (s, 1H), 8.45 (s, 1H); MS m/z 155 [M + 1]+.

References

[1] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 18
[2] Patent: WO2008/153947, 2008, A2. Location in patent: Page/Page column 42; 63-64
[3] Molecules, 2017, vol. 22, # 4,
[4] Patent: CN106496232, 2017, A. Location in patent: Paragraph 0049; 0050; 0051; 0052
[5] Patent: CN107383014, 2017, A. Location in patent: Paragraph 0075; 0076; 0077; 0078

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-1H-pyrazolo[3,4-d]pyrimidine Suppliers

Canada 2 China 208 Germany 3 India 8 Ukraine 1 United Kingdom 4 United States 26 Global 252

J & K SCIENTIFIC LTD.

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View Lastest Price from 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 6-Chloropurine 5399-92-8
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 6-Chloropurine 5399-92-8
Price: US $100.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 6-Chloropurine 5399-92-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-15

5399-92-8, 4-Chloro-1H-pyrazolo[3,4-d]pyrimidineRelated Search:

Trazodone Zolpidem tartrate Sodium cloxacillin monohydrate Cloxacillin Chlorzoxazone Pyrimidine Zolpidem 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE Difluorochloromethane ethyl 5,7-dichloro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylate 7-CHLORO-5-METHYLPYRAZOLO[1,5-A]PYRIMIDINE 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(4-METHOXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(2,4-DIMETHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(3,5-DI-O-TOLUOYL-BETA-D-2-DEOXYRIBOFURANOSYL)PYRAZOLO[3,4-D]PYRIMIDINE

IFLAB-BB F0909-0060

4-CHLORO-1H-PYRAZOLO3,4-DPYRIMIDINE

AKOS BBS-00002106

1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro-

4-Chloropyrazolo[3,4-d]pyrimidine

NSC 4937

4-chloro-1H-pyrazolo[3

4-Chlor-1(2)Hpyrazolo[3,4-d]pyriMidine

4-chloro-1(2)H-pyrazolo[3,4-d]pyriMidine

4-Chloro-1H-pyrazolo[3,4-d]pyriMidine, 95+%

4-chloro-1H-pyrazolo[4,3-e]pyrimidine

oro-1H-pyrazoL

o[3,4-d]pyrimidine

Ibrutinib Impurity 115

4-Chloro-5H-pyrazolo[3,4-d]pyrimidine

5399-92-8

Heterocycle-Pyrimidine series

Halides

Bases & Related Reagents

Heterocycles

Inhibitors

Nucleotides

Fused Ring Systems